FIGURE 3.
a) Relative mRNA expression of selected transcription factors in cultured immortalized human chondrocytes (TC28) treated with different doses of the DNA methylation inhibitor 5-Aza-2-deoxycytidine (5’Aza) for 48 hours. Values are expressed as mean ± SEM. * = P < 0.05 vs 0µM 5’Aza. b) Relative mRNA expression of selected transcription factors in cultured primary human chondrocytes from normal donors (N=5) treated with 5’Aza (10µM) or vehicle for 4 weeks. Values are expressed as mean ± SEM. * = P < 0.05.