Table 1.
Most differentially hypomethylated and hypermethylated CpG sites in knee articular cartilage from normal donors and osteoarthritis patients.
| Illumina probe ID | Associated gene symbol |
Δβ (Normal-OA) |
P-value | Corrected P-value |
|---|---|---|---|---|
| Hypomethylated in OA | ||||
| cg21465150 | TRPV3 | −0.45 | 1.96E-04 | 0.041057162 |
| cg07371504 | TRPV3 | −0.43 | 2.18E-04 | 0.043347392 |
| cg20092122 | BST2 | −0.40 | 1.26E-06 | 0.004419322 |
| cg06880930 | CPNE2 | −0.34 | 3.06E-06 | 0.006008504 |
| cg13030790 | RUNX1 | −0.33 | 2.35E-05 | 0.015638525 |
| cg15591803 | DENND2D | −0.31 | 1.32E-07 | 0.00200339 |
| cg01675238 | JMJD7 | −0.31 | 4.34E-06 | 0.00688781 |
| cg22714290 | LOC148696 | −0.30 | 5.86E-06 | 0.007902923 |
| cg09966895 | ODZ4 | −0.30 | 6.13E-07 | 0.003304806 |
| cg12273284 | CAMK1D | −0.29 | 2.73E-05 | 0.016527922 |
| cg03744842 | CCM2 | −0.29 | 3.31E-06 | 0.006090967 |
| cg11854227 | ILDR1 | −0.28 | 6.16E-07 | 0.003250758 |
| cg20054157 | SFTA1P | −0.27 | 1.05E-06 | 0.004161572 |
| cg00694560 | ILDR1 | −0.27 | 3.87E-10 | 6.27085E-05 |
| cg21108085 | CD82 | −0.26 | 1.39E-08 | 0.000615655 |
| cg25758828 | PAX8 | −0.26 | 5.12E-05 | 0.021732678 |
| cg16707506 | CCM2 | −0.26 | 1.04E-05 | 0.01049113 |
| cg07168232 | LAMB3 | −0.26 | 8.71E-06 | 0.009589979 |
| cg19919590 | LAPTM5 | −0.25 | 9.11E-06 | 0.009808833 |
| cg03357727 | ULK4 | −0.25 | 4.42E-06 | 0.006881195 |
| Hypermethylated in OA | ||||
| cg03358468 | KDM4B | 0.44 | 3.22E-07 | 0.002562628 |
| cg18536148 | TBX4 | 0.39 | 2.60E-06 | 0.005864998 |
| cg15517343 | NFATC1 | 0.34 | 2.79E-07 | 0.00260294 |
| cg14196395 | DYSF | 0.33 | 1.94E-05 | 0.014468514 |
| cg01789499 | PRDM8 | 0.33 | 9.45E-06 | 0.009995321 |
| cg10890644 | TUBAL3 | 0.32 | 1.10E-04 | 0.031613525 |
| cg26819718 | C10orf11 | 0.32 | 7.99E-05 | 0.027232593 |
| cg24274579 | TBX4 | 0.30 | 1.36E-06 | 0.004576905 |
| cg03311556 | PRDM8 | 0.30 | 3.07E-06 | 0.005983571 |
| cg22079102 | KDM4B | 0.30 | 2.90E-06 | 0.005832481 |
| cg13738327 | LRP5 | 0.30 | 6.44E-05 | 0.024342721 |
| cg14419393 | ASPSCR1 | 0.30 | 9.20E-05 | 0.028974493 |
| cg06365535 | TBX4 | 0.30 | 1.19E-07 | 0.001863844 |
| cg06440348 | PRDM8 | 0.29 | 1.61E-06 | 0.004952817 |
| cg01851968 | VASN | 0.29 | 9.97E-05 | 0.03017708 |
| cg22902505 | PRDM8 | 0.29 | 1.15E-06 | 0.00431253 |
| cg07727358 | FGFRL1 | 0.29 | 1.86E-05 | 0.01429792 |
| cg14619259 | SPRY4 | 0.29 | 4.73E-05 | 0.021123812 |
| cg16536399 | NFATC1 | 0.28 | 2.99E-05 | 0.017365227 |
| cg06458239 | ZNF549 | 0.28 | 5.73E-08 | 0.001210523 |