Table 3.

Expert panel recommendations for post-thrombotic syndrome (PTS) clinical trial.

Item	Recommendation
1	Perform multicenter RCT to assess EVT for iliac-obstructive PTS
2	Include patients with advanced PTS on Villalta or VCSS scales
3	Open-label study with blinded assessors and adjudicators
4	Primary outcome: change in VEINES-QOL measure at 6 months
5	Utilize run-in period to boost adherence, discourage crossover
6	Engage patient advocacy and health professional organizations
7	Encourage physical activity and risk factor modification
8	Non-proscriptive approach to medical PTS therapy
9	All patients use compression therapy (mainly graduated stockings)
10	Patients with active ulcer to be managed in specialized clinic
11	EVT = iliac vein stent placement followed by ablation of saphenous reflux
12	Early engagement of FDA around off-label use of stents

RCT, randomized controlled trial; EVT, endovascular therapy; VCSS, Venous Clinical Severity Score; VEINES-QOL, venous insufficiency epidemiological and economic study quality of life; FDA, Food and Drug Administration.