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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Antibiot (Tokyo). 2016 Apr 13;69(7):486–493. doi: 10.1038/ja.2016.39

Figure 10.

Figure 10

Alternative pentalenene synthase cyclization pathways proceeding through the 7-protoilludyl cation intermediate C predicted by quantum chemical calculations65 and supported by experimentally-measured kinetic isotope effects.64 Reprinted with permission from: Zu, L., Xu, M., Lodewyk, M. W., Cane, D. E., Peters, R. J., & Tantillo, D. J. Effects of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry. J. Am. Chem. Soc. 134, 11369–11371 (2012). Copyright 2012 American Chemical Society.