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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Antibiot (Tokyo). 2016 Apr 13;69(7):486–493. doi: 10.1038/ja.2016.39

Figure 4.

Figure 4

Proposed catalytic mechanism of kynureninase. The PLP-phosphate serves as a general base-general acid in the activation of Y226 for catalysis. Hydrolysis of the enamine product shown ultimately yields product alanine. Reprinted with permission from: Phillips, R. S. Chemistry and diversity of pyridoxal-5′-phosphate dependent enzymes. Biochim. Biophys. Acta – Prot. Proteomics. 1854, 1167–1174 (2015). Copyright 2015 Elsevier B.V.