Table 4.
Association of adiposity measures with calcified atherosclerotic plaque, full sample
| Full sample | ||||
|---|---|---|---|---|
| Presence | Severity | |||
| Calcified Plaque | OR (95% CI) | P-value | Estimate (SE) | P-value |
| Coronary Artery* | ||||
| BMI | 1.15 (0. 93,1.43) | 0.21 | 0.06 (0.08) | 0.41 |
| WC | 1.18 (0.95,1.45) | 0.13 | 0.08 (0.07) | 0.27 |
| PAT | 1.49 (1.10,2.03) | 0.011 | 0.06 (0.08) | 0.43 |
| VAT | 1.14 (0.82,1.57) | 0.44 | −0.001 (0.08) | 0.99 |
| SAT | 0.98 (0.76,1.27) | 0.88 | −0.01 (0.07) | 0.89 |
| Carotid Artery | ||||
| BMI | 0.90 (0.77,1.04) | 0.16 | 0.04 (0.08) | 0.61 |
| WC | 0.93 (0.80,1.07) | 0.31 | 0.02 (0.08) | 0.78 |
| PAT | 0. 90 (0.75,1.07) | 0.22 | −0.04 (0.07) | 0.56 |
| VAT | 0.92 (0.78,1.09) | 0.35 | −0.11 (0.07) | 0.11 |
| SAT | 0.89 (0.75,1.04) | 0.15 | −0.003 (0.07) | 0.97 |
| Aorta | ||||
| BMI | 0.86 (0.69,1.06) | 0.16 | −0.24 (0.08) | 0.002 |
| WC | 0.87 (0.71,1.07) | 0.19 | −0.28 (0.07) | <0.001 |
| PAT | 0.98 (0.74,1.31) | 0.92 | −0.04 (0.07) | 0.54 |
| VAT | 0.99 (0.73,1.36) | 0.97 | −0.15 (0.07) | 0.023 |
| SAT | 0.81 (0.63,1.03) | 0.09 | −0.21 (0.07) | 0.002 |
Estimates are per standard deviation increment in the full cohort: 7.8 kg/m2 BMI, 17.9 cm WC, 51.6 cm3 PAT, 130.6 cm3 VAT, and 213.2 cm3 SAT. Results were adjusted for age, gender, level of education, HbA1c, statins, smoking, prior CVD, hypertension, kidney disease, and C-reactive protein.
Participants who underwent coronary artery bypass grafting (31 AAs; 31 EAs), prior stenting and/or coronary angioplasty (84 AAs; 72 EAs) were excluded from severity of CAC analyses. BMI: body mass index; WC: waist circumference; PAT: pericardial adipose tissue; VAT: visceral adipose tissue; SAT: subcutaneous adipose tissue. Bolded p-values pass Bonferroni correction threshold of p<0.003 (0.05/15).