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. Author manuscript; available in PMC: 2016 Jul 27.
Published in final edited form as: Cell Rep. 2016 Jul 7;16(4):1106–1114. doi: 10.1016/j.celrep.2016.06.048

Fig 4. Post-Mendelian inheritance patterns of drug resistance in different hybrid contexts.

Fig 4

(A–D) Offspring fitness distribution patterns observed in hybrids originated from 20 sensitive isolates and YJM326 in the presence of cycloheximide (YPD CHX 1µg/ml). 80 offspring were tested for each case, and examples of Mendelian (A) and non-Mendedian (C–D) inheritance patterns are shown. Phenotypic segregation is indicated at the upper right side for cases with biased bimodal distributions (A and B). For cases with more complex patterns, maximum likelihood fittings of a bimodal model were shown instead (C and D). For nonbimodal cases the model fitting results were shown instead. Parental origins for each cross are shown, and the fitness values of the sensitive (red) or resistant (blue) parental strains are presented as vertical bars, with dotted bars corresponding to ± standard variation (N = 4). See Figure S4 for offspring fitness distributions for each of the 20 crosses, and additional offspring distributions for selected crosses with biased Mendelian patterns.