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. Author manuscript; available in PMC: 2017 Jul 26.
Published in final edited form as: Circulation. 2016 Jul 26;134(4):270–285. doi: 10.1161/CIRCULATIONAHA.116.021803

Figure 4. Top protein associations with the Framingham Risk Score (FRS) and component clinical traits.

Figure 4

Shown are the top 30 proteins with positive (Panel A) and negative (Panel B) associations. Within groups of positive/negative associations, proteins are sorted by ascending P. Estimated beta coefficients and P were generated from age- and sex- adjusted regression analyses of each protein (log transformed then standardized) with FRS and clinical traits (standardized). The size of the circles corresponds to P (larger circles represent smaller P). Protein-trait associations with P > 5.54E-06 were not represented by circles. The color of the circles represents estimated beta coefficients as denoted in the key above. Abbreviations: FRS: Framingham Risk Score, TC: total cholesterol, HDL: high-density lipoprotein, SBP: systolic blood pressure. Diabetes and current smoking status were categorical variables. See Supplemental Table 1 for full protein names, Entrez Gene symbol/ID and UniProt ID.