Table 3.

Top FHS protein associations with incident cardiovascular disease (age- and sex-adjusted)

Protein	HR per s.d. (CI)	P
tPA	1.65 (1.31–2.07)	2.1E-05
Cathepsin H	1.47 (1.21–1.79)	1.3E-04
NCAM 120	0.68 (0.55–0.83)	2.5E-04
IDS	0.69 (0.56–0.85)	3.9E-04
C1s	1.42 (1.17–1.73))	5.1E-04
IGFBP4	1.48 (1.18–1.86)	7.8E-04

Shown are proteins with P < 0.001, listed by ascending P. Values are hazard ratios per standard deviation (95% confidence intervals) for incident CVD from proportional hazards regression models. See Supplemental Table 1 for full protein names, Entrez Gene symbol/ID and UniProt ID.