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. Author manuscript; available in PMC: 2016 Aug 17.
Published in final edited form as: Mucosal Immunol. 2016 Jan 27;9(5):1317–1329. doi: 10.1038/mi.2015.138

Figure 1.

Figure 1

Loss of PTP1B expression enhances lung remodeling. (A) Enhanced PTP1B activity is observed in the lungs of FVB/NJ mice exposed to 2 weeks (acute) of cigarette smoke exposure but not following 6 months (chronic) of exposure. (B) Ptp1b-/- mice and their FVB/NJ wild type littermates were exposed to four months of cigarette smoke or room air. Bronchoalveolar lavage fluid immune cellularity was enhanced by smoke exposure and was further enhanced by loss of Ptp1b expression. (C) Mean linear intercepts (MLI) were measured in the lungs of the mice to assess lung remodeling and comparative histology images of the four mouse groups are presented here (scale bar=40 μm). Slides were randomized, read blindly and scored for MLI. Graphs are represented as mean ± S.E.M, where n= at least 10 animals per group for each time point. p values are shown comparing both groups connected by a line.