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. Author manuscript; available in PMC: 2016 Aug 17.
Published in final edited form as: Mucosal Immunol. 2016 Jan 27;9(5):1317–1329. doi: 10.1038/mi.2015.138

Figure 3.

Figure 3

Ptp1b deficient mice display enhanced lung damage and cytokines during RSV infection. (A) Ptp1b-/- mice (triangle) and their FVB/NJ wild-type littermates (circle) were infected with 1×106 pfu of RSV (closed) or mock control (open) and animals were euthanized on days 0, 1, 3, 5, 7 and 9-dpi. Ptp1b-/- mice have enhanced protein content in BALF compared to wild-type mice. Ptp1b-/- mice display greater lung apoptosis. * p < 0.05 compared to wild-type mice on each corresponding time point. (B) Loss of PTP1B expression enhances caspase-3 cleavage and activation as determined by caspase-3 immunoblots conducted on lung tissue lysates. (C) BALF levels of MCP-1, G-CSF, CXCL10, CXCL1, CXCL9, PDGF-bb, RANTES, IFN-γ, Eotaxin, IL-4, IL-5 and IL-13 were determined in both mouse genotypes following 5 dpi. Graphs are represented as mean ± S.E.M, where n= at least 10 per group for each time point. p values shown, comparing both treatments connected by a line.