Skip to main content
. Author manuscript; available in PMC: 2016 Aug 17.
Published in final edited form as: Mucosal Immunol. 2016 Jan 27;9(5):1317–1329. doi: 10.1038/mi.2015.138

Figure 5.

Figure 5

Infiltration of immune cells following RSV-infection is diminished upon neutralization of extracellular S100A9 signaling. (A) Wild type and Ptp1b-/- mice were IP injected with isotype control IgG or anti-S100A9 IgG prior to intranasal infection with 1×106 pfu of RSV and animals were euthanized 2, 5 and 8-days post infections. (B) Animal body weight and (C) BALF cellularity (total BAL cells, macrophages, neutrophils, lymphocytes and eosinophils) were determined in each group (white background = wild type and grey area = Ptp1b-/- mice). (D) Comparative histology images of infected animals 5 dpi are presented here (scale bar=50 μm). Histopathology (Peribronchiolitis, perivasculitis and alveolitis scoring) was recorded in mice for each group. Slides were randomized, read blindly and scored for each parameter. Graphs are represented as mean ± S.E.M., where each measurement was performed 3 times on 10 animals/group. * p < 0.05 or p values shown, comparing both treatments connected by a line.