Table 3.
Recommended HCV Treatment Regimen for Patients with Decompensated Cirrhosis.
| Genotype | Recommended regimen |
|---|---|
| 1 & 4 | • SOF + LDV + RBV (initial dose of 600 mg, increased as tolerated) × 12 weeks • SOF + DCV + RBV (initial dose of 600 mg, increased as tolerated) × 12 weeks Alternative regimen for RBV-intolerant patients • SOF + DCV × 24 weeks • SOF + LDV × 12 weeks |
| 2 | • SOF + DCV + RBV (initial dose of 600 mg, increased as tolerated) × 12 weeks |
| 3 | • SOF + DCV + RBV (initial dose of 600 mg, increased as tolerated) × 24 weeks Alternative regimen • SOF + RBV (initial dose of 600 mg, increased as tolerated) for up to 48 weeks |
DCV, daclatasvir (60 mg); LDV, ledipasvir (90 mg); RBV, Ribavirin; SOF, sofosbuvir