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Primary hepatocytes cultured on matrigel and collagen type I. (a) Bile acid levels in cell culture medium. (b) CYP7A1 mRNA expression. (c) CYP8B1 mRNA expression. Data represent means ± SEM, A. U., arbitrary unit, * P ≤ 0.05, *** P ≤ 0.01, n = 4 livers.
