Table 1. Genes and potential biomarkers identified for HCC-CC, HCC, CC and associated conditions.
| Conditions | Total genes |
|---|---|
| HCC-CC | 50 |
| HCC | 690 |
| HCC pathologic subtypes | |
| Fibrolamellar HCC | 5 |
| Scirrhous HCC | 2 |
| Sarcomatoid HCC | 11 |
| Lympho-epithelial-like HCC | 94 |
| HCC risk factors | |
| Cirrhosis | 352 |
| Portal hypertension | 30 |
| Infectious | |
| Hepatitis C | 272 |
| Hepatitis B | 293 |
| Toxin | |
| Alcoholic fatty liver | 30 |
| Aflatoxin | 6 |
| Peliosis hepatis | 2 |
| Autoimmune | |
| Autoimmune hepatitis | 206 |
| Primary biliary cirrhosis | 118 |
| Granulomatous, hepatitis | 11 |
| Metabolic | |
| Fatty liver disease | 125 |
| Nonalcoholic steatohepatitis | 9 |
| Hemochromatosis | 52 |
| Glycogen storage diseases | 52 |
| Wilson disease | 26 |
| Porphyria cutanea tarda | 20 |
| Alpha-1, antitrypsin | 20 |
| Tyrosinemia | 15 |
| Vascular | |
| Portal vein thrombosis | 9 |
| Budd-Chiari syndrome | 5 |
| CC | 98 |
| CC pathologic subtypes | |
| Intraductal papillary CC | 2 |
| Intestinal-type CC | 8 |
| Clear cell CC | 12 |
| Signet-ring CC | 0 |
| Squamous Cell CC | 54 |
| Small cell CC | 39 |
| CC risk factors | |
| Primary sclerosing cholangitis | 41 |
| Congenital | |
| Cystic disease of liver | 97 |
| Biliary cyst | 20 |
| Choledochal cyst | 8 |
| Caroli disease | 2 |
| Other congenital malformations of bile ducts | 1 |
| Other congenital malformations of gallbladder | 1 |
| Infectious | |
| Cholangitis | 58 |
| Schistosomiasis | 43 |
| Opisthorchiasis | 12 |
| Clonorchiasis | 12 |
| Recurrent cholangitis | 7 |
| Anatomic | |
| Biliary stricture | 2 |
HCC-CC, hepatocellular carcinoma-cholangiocarcinoma; HCC, hepatocellular carcinoma; CC, cholangiocarcinoma.