Table 1.

Selection of deubiquitylating enzymes (DUBs) involved in modulating histone H2A/B ubiquitylation.

DUB	Histone (substrate)	Process	Selected reference
USP3	H2A, γH2AX and H2B	Cell cycle and DNA double-strand break response	Nicassio et al., 2007
USP7	H2A and H2B	Gene expression	van der Knaap et al., 2005; Luo et al., 2015
USP10	H2A (H2A.Z)	Transcriptional activation	Draker et al., 2011
USP12	H2A and H2B	Xenopus development	Joo et al., 2011
USP16	H2A	Cell cycle and gene expression	Joo et al., 2007; Gu et al., 2016
USP21	H2A	Transcriptional activation	Nakagawa et al., 2008
USP22	H2A and H2B	Embryonic development and telomere integrity	Zhang et al., 2008a,b; Atanassov et al., 2009; Wang and Dent, 2014
USP29	H2A and H2B	DNA double-strand break response	Mosbech et al., 2013
USP36	H2B	Unknown	Taillebourg et al., 2012
USP44	H2A and H2B	DNA double-strand break response (H2A) and stem cell differentiation (H2B)	Fuchs et al., 2012; Mosbech et al., 2013
USP46	H2A and H2B	Xenopus development	Joo et al., 2011
USP49	H2B	Co-transcriptional pre-mRNA processing	Zhang et al., 2013
BAP1	H2A	Gene expression	Scheuermann et al., 2010
OTUB1	Histones (unspecified)	DNA double-strand break response	Sato et al., 2012
BRCC36	H2A and γH2AX	DNA double-strand break response	Shao et al., 2009
MYSM1	H2A	Gene expression	Zhu et al., 2007; Jiang et al., 2015; Li et al., 2016