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. 2016 Jul;32(4):428–438. doi: 10.6515/ACS20150731C

Table 4. Independent prognostic determinants of composite MACCE by univariate and multivariate analysis.

Parameters MACCE (+) (n = 84) MACCE (-) (n= 183) Univariate Multivariate
p value p value
Tele-ECG group 24 (27.3) 78 (42.4%) 0.016 0.003
Age (years) 64.5 ± 14 61.4 ± 13 0.081
Male 68 (77%) 155 (84%) 0.179
Diabetes 31 (35%) 59 (32%) 0.68
Hypertension 48 (54.5%) 91 (49.5%) 0.44
Smoking 19 (21.6%) 27 (14.7%) 0.169
Hyperlipidemia 28 (31.8%) 78 (42.4%) 0.111
Prior myocardial infarction 14 (15.9%) 20 (10.9%) 0.245
Prior stroke 1 (1.1%) 7 (3.8%) 0.444
Prior CABG 3 (3.4%) 6 (3.3%) 1
Prior PCI 5 (5.7%) 11 (6.0%) 1
Prior valvular heart disease 1 (1.1%) 5 (2.7%) 0.667
Number of diseased vessels 0.023 0.128
 1 32 (31%) 27 (16%)
 2 40 (39%) 71 (42%)
 3 30 (29%) 71 (42%)
Location of lesion 0.43
 LAD 45 (47%) 77 (48%)
 LCX 11 (12%) 25 (16%)
 RCA 39 (41%) 59 (37%)
LAD involved 45 (51.1%) 79 (42.9%) 0.242
Use of drug eluting stent 25 (28%) 69 (38%) 0.11
Prehospital on-scene time, hours (IQR) 3.8 (1.63-7.51) 3.2 (1.88-9.6) 0.329
D2BT_min, median (IQR) 117 (87-182) 91 (75-135) 0.022
D2BT ≤ 90 minutes goal 29 (35%) 85 (43%) 0.06
Parameters at presentation
 SBP (mmHg) 130 ± 28 136 ± 31 0.09
 DBP (mmHg) 79 ± 18 84 ± 21 0.058
 Heart rate (per minute) 79 ± 21 75 ± 20 0.102
 WBC (/μl) 11,253 ± 3,642 10,496 ± 3,252 0.085
 NLR, median (IQR) 3.9 (2.2-7.45) 2.9 (1.68-5.2) 0.003 0.372
GRACE score 141 ± 32 132 ± 34 0.047
GRACE score ≥ 144 41 (48.8) 67 (36.6%) 0.062
Initial troponin I 13.8 ± 25.4 7.9 ± 20.9 0.06
Cholesterol (mg/dl) 174 ± 38 180 ± 46 0.299
Triglyceride (mg/dl) 137 ± 86 141 ± 121 0.795
Creatine (mg/dl) 1.2 ± 1 1.2 ± 1.1 0.823
Glucose (gm/dL) 194 ± 105 171 ± 79 0.077
Peak CK (μ/ml) 2,364 ± 2,201 2,645 ± 2,251 0.333
Peak CK-MB (μ/ml) 115 ± 2,201 135 ± 2,251 0.234
Peak Troponin I (μ/ml) 77.3 ± 101.7 86.4 ± 103.5 0.497
LV ejection fraction (%) 43 ± 10 42 ± 11 0.639
Moderate to severe MR (%) 19 (23%) 21 (74%) 0.027 0.029

CABG, coronary artery bypass grafting; CAD, coronary artery disease; CK, creatinine kinase; CK-MB, creatinine kinase MB isoenzyme; DBP, diastolic blood pressure; D2BT, door to balloon time; ECG, electrocardiography; GRACE, Global Registry of Acute Coronary Events; LAD, left anterior descending coronary artery; LCX, left circumflex coronary artery; LV, left ventricle; MACCE, major cardiac and cerebral adverse events; MR, mitral regurgitation; NLR, neutrophil-lymphocyte ratio; PCI, percutaneous coronary intervention; RCA, right coronary artery; SBP, systolic blood pressure; WBC, white blood cell.