Effects of acetaminophen and L-NAME on the diastolic tension and action potential (AP) of the left atrium (LA). (A) Tracing and average data of the diastolic tension of the LA (n = 7) before and after administration of L-NAME and acetaminophen. (B) Superimposed tracings and average data of the AP and contractility in the LA (n = 7) before and after administration of L-NAME and acetaminophen. * p < 0.05, # p < 0.01, † p < 0.005 versus the baseline. APA, AP amplitude; APD20, APD50, and APD90, AP duration at a repolarization of 20%, 50%, and 90% of the APA, respectively; RMP, resting membrane potential.