TABLE 3.
In vitro susceptibility of 172 isolates of C. guilliermondii and C. fermentati to nine antifungal agents as interpreted by breakpoints for three echinocandins and epidemiological cutoff values for other agents
| C. guilliermondii complex (no. of isolates) | MIC(mg/liter) |
No. (%) of isolates by ECVsa |
No. (%) of isolates by BPsb |
|||||
|---|---|---|---|---|---|---|---|---|
| Range | MIC50 | MIC90 | WT | non-WT | S | I | R | |
| C. guilliermondii (164) | ||||||||
| Fluconazole | 1–>256 | 2 | 16 | 146 (89.0) | 18 (11.0) | |||
| Itraconazole | 0.06–>16 | 0.12 | 0.5 | 159 (96.9) | 5 (3.1) | |||
| Voriconazole | 0.015–>8 | 0.06 | 0.25 | 148 (90.2) | 16 (9.8) | |||
| Posaconazole | 0.015–>8 | 0.12 | 5 | 157 (95.7) | 7 (4.3) | |||
| 5-Flucytosine | ≤0.06–>64 | 0.06 | 0.06 | 154 (93.9) | 10 (6.1) | |||
| Caspofungin | 0.06–>8 | 0.25 | 1 | 163 (99.4) | 0 (0) | 1 (0.6) | ||
| Micafungin | 0.06–>8 | 0.25 | 1 | 161 (98.2) | 1 (0.6) | 2 (1.2) | ||
| Anidulafungin | 0.06–>8 | 1 | 2 | 159 (97.0) | 2 (1.2) | 3 (1.8) | ||
| Amphotericin B | 0.12–1 | 0.25 | 0.5 | 164 (100) | 0 (0) | |||
| C. fermentati (8) | ||||||||
| Fluconazole | 1–4 | 8 (100) | 0 (0) | |||||
| Itraconazole | 0.06–0.5 | 8 (100) | 0 (0) | |||||
| Voriconazole | 0.015–0.12 | 8 (100) | 0 (0) | |||||
| Posaconazole | 0.015–0.25 | 8 (100) | 0 (0) | |||||
| 5-Flucytosine | ≤0.06 | 8 (100) | 0 (0) | |||||
| Caspofungin | 0.03–0.5 | 8 (100) | 0 (0) | 0 (0) | ||||
| Micafungin | 0.03–0.5 | 8 (100) | 0 (0) | 0 (0) | ||||
| Anidulafungin | 0.03–2 | 8 (100) | 0 (0) | 0 (0) | ||||
| Amphotericin B | 0.12–0.5 | 8 (100) | 0 (0) | |||||