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. 2016 Jul 26;7:12359. doi: 10.1038/ncomms12359

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Copyright © 2016, The Author(s)

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(a) The elbow joint of Clone 388 appears normal: there is no radiographic evidence of osteoarthritis. (b) The elbow joint of Clone 2262 shows evidence of severe osteoarthritis. Large osteophytes representing new bone formation are apparent at the joint margins (white arrows), and are associated with bone remodelling. This elbow was scored as Grade 3 on the modified scale of Kellgren and Lawrence⁴⁰.