FIG 4 .

(A) PCA results for all data, with individual samples plotted on principal component 1 (horizontal axis) and principal component 2 (vertical axis). (B) Graphical representation of the gene enrichment process using Degust. Individual differentially regulated genes are represented as horizontal red lines. The vertical axes represent the log₂ fold change of all genes at each time point in control and treated conditions (indicated above each axis) relative to 15 min of treatment with FADDI-019. Gray boxes indicate the gating cutoffs used to enrich the gene list for genes that are greater than 1 log₂ fold differentially expressed throughout the control samples but >1 log₂ fold differentially expressed after 60 min.