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(A) Metabolic pathways of the amino acid biosynthesis affected by FADDI-019 treatment. (B) Tetrahydrofolate pathway affected by FADDI-019 treatment. (C) Tetrahydrofolate biosynthesis pathway targeted by sulfamethoxazole and trimethoprim. Arrows indicate reactions catalyzed by known enzymes in S. aureus 700698, and red arrows indicate reactions catalyzed by enzymes with >2-fold increased expression.
