Table 3.
Differences in patient characteristics by final antibiotic grouping.
| Deescalation (n = 189) | No change (n = 156) | Escalation (n = 42) | Mixed changes (n = 8) | p value | |
|---|---|---|---|---|---|
| SAPS II | 48 ± 19.5 | 41 ± 19 | 47 ± 18.5 | 44 ± 23.7 | 0.007 |
| Admission procalcitonin | 2.3 (IQR 0.7–7.4) |
7.9 (IQR 2–33.6) |
4.6 (IQR 1.1–11.1) |
11.1 (IQR 7–15.3) |
0.007 |
| No growth | 86 (45.5%) | 102 (65.3%) | 12 (28.5%) | 0 | <0.001 |
| Single site of sepsis | 60 (31.7%) | 35 (22.4%) | 22 (52.3%) | 3 (37.5%) | 0.002 |
| MDR organism | 12 (6.3%) | 22 (14.1%) | 5 (11.9%) | 2 (25%) | 0.05 |
| Fungal sepsis | 11 (5.8%) | 15 (9.6%) | 8 (19%) | 2 (25%) | 0.019 |
| ICU length of stay | 6.5 (IQR 4.2–44) |
5.5 (IQR 4–17) |
5 (IQR 4–36.5) |
7.5 (IQR 5–33.2) |
0.003 |
| ICU mortality | 28 (14.8%) | 38 (24.4%) | 6 (14.3%) | 2 (25%) | 0.11 |