Table 3.
Clinicopathological characteristics of gastric cancer samples and ADAMTS8 methylation.
| Variable | Patients (n) | ADAMTS8 methylation | P value | |
|---|---|---|---|---|
| M (%) | U (%) | |||
| Age (years) | ||||
| <65 | 40 | 25 (62.5) | 15 (37.5) | |
| ≥65 | 26 | 15 (57.7) | 11 (42.3) | 0.365 |
| Gender | ||||
| Male | 45 | 29 (64.4) | 16 (35.6) | |
| Female | 21 | 11 (52.4) | 10 (47.6) | 0.219 |
| Tumor differentiation | ||||
| Well/moderate | 33 | 23 (69.7) | 10 (30.3) | |
| Poor | 33 | 17 (51.5) | 16 (48.5) | 0.614 |
| Invasive depth | ||||
| T1 + T2 | 22 | 10 (40.9) | 12 (59.1) | |
| T3 + T4 | 44 | 30 (70.5) | 14 (29.5) | 0.075 |
| Tumor location | ||||
| Upper + middle | 13 | 8 (61.5) | 5 (38.5) | |
| Lower | 53 | 32 (60.4) | 21 (39.6) | 0.478 |
| Size (cm) | ||||
| <3 | 28 | 15 (53.6) | 13 (46.4) | |
| ≥3 | 38 | 25 (65.8) | 13 (34.2) | 0.621 |
| Lymph node metastasis | ||||
| No | 20 | 7 (35.0) | 13 (65.0) | |
| Yes | 46 | 33 (71.3) | 13 (28.7) | 0.005a |
a P < 0.05. M: methylated and partially methylated cases; U: unmethylated cases; ADAMTS8: ADAM metallopeptidase with thrombospondin type 8 motif.