14. Ongoing or planned RCTs.

Trial name	Relevant intervention	Relevant outcome	Target population	Location(s)	Estimated completion date
Reduction of EArly mortaLITY in HIV‐infected Adults and Children Starting Antiretroviral Therapy (REALITY)	Immediate enhanced opportunistic infections (OI) prophylaxis with isoniazid/pyridoxine and cotrimoxazole, plus 12 weeks fluconazole, 5 days azithromycin, and a single dose of albendazole versus cotrimoxazole prophylaxis alone for the first 12 weeks followed by isoniazid and any prophylaxis and/or treatment prescribed at screening	• Change in CD4 count • Adverse events	HIV‐infected individuals ages ≥ 5 years	Kenya, Malawi, Uganda, Zimbabwe	February 2016
Can Anthelminthic Treatment Delay the Progression of HIV? Randomised Open‐label Trial Testing Presumptive Anthelminthic Treatment on Progression of HIV in ART‐naïve HIV‐positive Patients in a Rural African Setting With Presumed High Prevalence of Helminth Infections	Standard HIV care with provision of praziquantel, albendazole, and ivermectin at baseline, after 6 months, and after 12 months versus standard HIV care with no anthelminthic treatment	• Change in viral load • Change in CD4 count • Adverse event	HIV‐infected individuals aged ≥ 18 years	Tanzania	Terminated prematurely due to recruitment difficulties

Abbreviations: RCT: randomized controlled trial; HIV: human immunodeficiency virus; ART: antiretroviral.