Table 4.
Association of genomic gain/loss with overall survival in four independent datasets of DLBCL patients treated with RCHOP or RCHOP-like regimens.
| MCR CNA (Aberration Number, Cytoband) | DS-169 (n=70) | DS-124 | DS-41 | DS-66 | ||||
|---|---|---|---|---|---|---|---|---|
| Freq | P-value | Freq | P-value | Freq | P-value | Freq | P-value | |
| A12q13.11-q13.12 (Ab14, 12q13) | 11.4% | 0.042 | 3.2% | 0.293 | 31.7% | 0.511 | 21.2% | 0.98 |
| A12q14.2-q21.1 (Ab15, 12q15) | 14.3% | 0.024 | 4.8% | 0.549 | 26.8% | 0.508 | 22.7% | 0.91 |
| A19q13.33-q13.43 (Ab26, 19q13) | 12.9% | <0.001 | 0.8% | ND | 9.8% | 0.066 | 9.1% | 0.82 |
| D6q11.1-q27 (Ab36, 6q21) | 27.1% | 0.709 | 13.7% | 0.709 | 19.5% | 0.005 | 33.3% | 0.98 |
| D6q11.1-q27 (Ab37, 6q21) | 25.7% | 0.83 | 14.5% | 0.604 | 14.6% | 0.002 | 30.3% | 0.82 |
| D8p22-p21.3 (Ab40, 8p21.3) | 7.1% | 0.437 | 5.6% | 0.023 | 2.4% | ND | 4.5% | 0.48 |
| D9p21.3 (Ab42, 9p21.3) | 20.0% | 0.447 | 3.2% | 0.345 | 9.8% | 0.008 | 13.6% | 0.58 |
| D15q15.1-q21.1 (Ab45, 15q15.2) | 8.6% | 0.098 | 8.9% | 0.039 | 19.5% | 0.128* | 19.7% | 0.37 |
| D17p13.3-p11.2 (Ab48, 17p13.1) | 10.0% | 0.021 | 12.9% | 0.344 | 24.4% | 0.972 | 18.2% | 0.2 |
| D17p13.3-p11.2 (Ab49, 17p13.1) | 10.0% | 0.021 | 12.9% | 0.344 | 24.4% | 0.972 | 16.7% | 0.13 |
Freq, Frequency; ND, not done
Trending with longer OS