Table 7.

OSIRIS-Property-Explorer (Actelion Pharmaceuticals Ltd, Allschwil, Switzerland) toxicological and physicochemical predicted properties.

	Property	1	Epoxide of 1	2
Toxicological risk	Mutagenicity	N	M	N
	Tumorigenicity	N	M	H
	Irritating effects	H	H	H
	Reproductive effects	H	H	H
Physicochemical properties	clog P	1.634	1.816	2.126
	log S	−3.266	−3.294	−3.182
	DL	−2.729	−2.017	−4.58
	DS	0.165	0.107	0.09

1: aflatoxin B₁, 2: 8-chloro-9-hydroxy-aflatoxin B₁. N = no risk, M = medium risk, H = High risk. DL = drug likeness, DS = drug score.