Fig. 3.

Burn wounds were treated with cadaveric bone marrow mesenchymal stem cells (CMSCs) and covered by a transparent polymeric film. a The patient at 1 week after deep escharotomy and first treatment with CMSCs and films. All the lesions have been washed and new film applied. Right axilla was also seen before film application. b First film change at first week after the CMSC treatment. The granulation-like tissue was seen under the film without much exudate. c–e One week after the first CMSC treatment, a granulation-like tissue was seen before first film replacement. The granulation-like tissue was probably a very early vascularized “neo-dermal like matrix” after CMSCs treatment under an active growth and differentiation natural program. This new matrix behaved as a novel and may be also “universal” scaffold allowing very well for autologous meshed skin graftings (AMSGs) attachment and maybe later appearance of keratinocytes and the production of a mature epidermis. f Wound epithelialization at second week after treatment with CMSCs. Rapid epithelialization from the edges and some epithelial growth in the center of the lesion was observed