Table 4.
Locus | Genotypes | C10:0 | C12:0 | C14:0 | C14:1 | ||
---|---|---|---|---|---|---|---|
rs136947640 | CC(248) | 2.13 ± 0.06 | 2.63 ± 0.08 | 9.55 ± 0.13 | 0.79 ± 0.03 | ||
TT(2) | 2.23 ± 0.24 | 2.66 ± 0.32 | 8.92 ± 0.54 | 0.65 ± 0.16 | |||
CT(64) | 2.09 ± 0.07 | 2.56 ± 0.09 | 9.42 ± 0.15 | 0.78 ± 0.04 | |||
P-value | 0.6139 | 0.5290 | 0.2611 | 0.6836 | |||
rs41919999 | CC(64) | 2.13 ± 0.07AB | 2.68 ± 0.09AB | 9.64 ± 0.15A | 0.76 ± 0.04 | ||
TT(88) | 1.99 ± 0.07B | 2.53 ± 0.09B | 9.25 ± 0.14B | 0.79 ± 0.04 | |||
CT(162) | 2.15 ± 0.06A | 2.73 ± 0.08A | 9.52 ± 0.13A | 0.80 ± 0.03 | |||
P-value | 0.0012 | 0.0041 | 0.0071 | 0.6264 | |||
rs132865003 | CC(220) | 2.11 ± 0.06 | 2.68 ± 0.08 | 9.52 ± 0.13 | 0.80 ± 0.03 | ||
TT(10) | 2.17 ± 0.12 | 2.72 ± 0.16 | 9.45 ± 0.26 | 0.75 ± 0.08 | |||
CT(85) | 2.11 ± 0.06 | 2.68 ± 0.08 | 9.49 ± 0.14 | 0.78 ± 0.04 | |||
P-value | 0.8601 | 0.9610 | 0.9217 | 0.7157 | |||
rs134340637 | AA(10) | 2.17 ± 0.12 | 2.72 ± 0.16 | 9.45 ± 0.26 | 0.75 ± 0.08 | ||
GG(220) | 2.11 ± 0.06 | 2.68 ± 0.08 | 9.52 ± 0.13 | 0.80 ± 0.03 | |||
AG(85) | 2.11 ± 0.06 | 2.68 ± 0.08 | 9.49 ± 0.14 | 0.78 ± 0.04 | |||
P-value | 0.8601 | 0.9610 | 0.9217 | 0.7157 | |||
rs41919992 | CC(157) | 2.05 ± 0.06A | 2.53 ± 0.08A | 9.31 ± 0.13A | 0.77 ± 0.04 | ||
TT(24) | 2.06 ± 0.09AB | 2.45 ± 0.12A | 9.35 ± 0.20A | 0.76 ± 0.06 | |||
CT(133) | 2.20 ± 0.06B | 2.74 ± 0.08B | 9.75 ± 0.13B | 0.79 ± 0.04 | |||
P-value | 0.0013 | <.0001 | <.0001 | 0.6169 | |||
rs133498277 | CC(157) | 2.05 ± 0.06A | 2.53 ± 0.08A | 9.32 ± 0.13A | 0.77 ± 0.04 | ||
TT(23) | 2.07 ± 0.09AB | 2.47 ± 0.12A | 9.42 ± 0.20AB | 0.75 ± 0.06 | |||
CT(134) | 2.18 ± 0.06B | 2.73 ± 0.08B | 9.75 ± 0.13B | 0.79 ± 0.04 | |||
P-value | 0.0043 | 0.0003 | <.0001 | 0.6826 | |||
rs41919984 | CC(157) | 2.06 ± 0.09AB | 2.51 ± 0.11A | 9.38 ± 0.19AB | 0.76 ± 0.06 | ||
TT(24) | 2.04 ± 0.06B | 2.58 ± 0.08A | 9.29 ± 0.13B | 0.78 ± 0.04 | |||
TC(134) | 2.19 ± 0.06A | 2.81 ± 0.08B | 9.74 ± 0.13A | 0.80 ± 0.04 | |||
P-value | 0.0010 | <.0001 | <.0001 | 0.6958 | |||
rs41919985 | AA(25) | 2.08 ± 0.09AB | 2.54 ± 0.11A | 9.46 ± 0.19AB | 0.76 ± 0.06 | ||
GG(157) | 2.04 ± 0.06B | 2.58 ± 0.08A | 9.28 ± 0.13B | 0.78 ± 0.04 | |||
GA(133) | 2.18 ± 0.06A | 2.80 ± 0.08B | 9.73 ± 0.13A | 0.80 ± 0.04 | |||
P-value | 0.0017 | <.0001 | <.0001 | 0.7268 | |||
rs41919986 | CC(155) | 2.03 ± 0.06A | 2.54 ± 0.08A | 9.36 ± 0.13A | 0.77 ± 0.04 | ||
TT(25) | 2.08 ± 0.09AB | 2.50 ± 0.11A | 9.50 ± 0.19AB | 0.76 ± 0.06 | |||
CT(132) | 2.17 ± 0.06B | 2.74 ± 0.08B | 9.78 ± 0.13B | 0.79 ± 0.04 | |||
P-value | 0.0015 | 0.0002 | <.0001 | 0.7225 | |||
Locus | Genotypes | C16:0 | C16:1 | C18:0 | C18:1n9c | C18:2n6c | CLA |
rs136947640 | CC(248) | 32.30 ± 0.33 | 1.75 ± 0.05 | 12.59 ± 0.17 | 29.36 ± 0.22 | 4.03 ± 0.03A | 0.38 ± 0.01 |
TT(2) | 32.38 ± 1.52 | 1.86 ± 0.21 | 12.25 ± 0.85 | 30.18 ± 1.13 | 3.73 ± 0.13A | 0.38 ± 0.05 | |
CT(64) | 32.17 ± 0.40 | 1.81 ± 0.06 | 12.54 ± 0.21 | 29.36 ± 0.28 | 4.12 ± 0.03B | 0.40 ± 0.01 | |
P-value | 0.9155 | 0.3007 | 0.9028 | 0.7714 | <.0001 | 0.3536 | |
rs41919999 | CC(64) | 32.22 ± 0.40 | 1.79 ± 0.06 | 12.31 ± 0.21 | 29.43 ± 0.28 | 4.09 ± 0.03 | 0.40 ± 0.01 |
TT(88) | 32.23 ± 0.38 | 1.77 ± 0.05 | 12.68 ± 0.20 | 29.82 ± 0.27 | 4.08 ± 0.03 | 0.38 ± 0.01 | |
CT(162) | 32.11 ± 0.34 | 1.76 ± 0.05 | 12.50 ± 0.17 | 29.36 ± 0.23 | 4.07 ± 0.03 | 0.39 ± 0.01 | |
P-value | 0.8921 | 0.7478 | 0.2182 | 0.0982 | 0.5542 | 0.4618 | |
rs132865003 | CC(220) | 32.24 ± 0.33 | 1.75 ± 0.05 | 12.54 ± 0.17 | 29.44 ± 0.22 | 4.06 ± 0.03a | 0.38 ± 0.01 |
TT(10) | 32.65 ± 0.73 | 1.78 ± 0.10 | 12.43 ± 0.40 | 28.95 ± 0.54 | 4.00 ± 0.06ab | 0.41 ± 0.02 | |
CT(85) | 32.19 ± 0.36 | 1.80 ± 0.05 | 12.46 ± 0.19 | 29.35 ± 0.25 | 4.12 ± 0.03b | 0.40 ± 0.01 | |
P-value | 0.8073 | 0.4185 | 0.8504 | 0.6087 | 0.0128 | 0.1185 | |
rs134340637 | AA(10) | 32.65 ± 0.73 | 1.78 ± 0.10 | 12.43 ± 0.40 | 28.95 ± 0.54 | 4.00 ± 0.06ab | 0.41 ± 0.02 |
GG(220) | 32.24 ± 0.33 | 1.75 ± 0.05 | 12.54 ± 0.17 | 29.44 ± 0.22 | 4.06 ± 0.03b | 0.38 ± 0.01 | |
AG(85) | 32.19 ± 0.36 | 1.80 ± 0.05 | 12.46 ± 0.19 | 29.35 ± 0.25 | 4.12 ± 0.03a | 0.40 ± 0.01 | |
P-value | 0.8073 | 0.4185 | 0.8504 | 0.6087 | 0.0128 | 0.1185 | |
rs41919992 | CC(157) | 32.21 ± 0.35 | 1.79 ± 0.05 | 12.67 ± 0.18 | 29.68 ± 0.24A | 4.05 ± 0.03 | 0.39 ± 0.01 |
TT(24) | 31.62 ± 0.54 | 1.80 ± 0.08 | 12.69 ± 0.29 | 30.64 ± 0.39C | 4.02 ± 0.04 | 0.38 ± 0.02 | |
CT(133) | 32.42 ± 0.35 | 1.73 ± 0.05 | 12.45 ± 0.18 | 28.89 ± 0.24B | 4.05 ± 0.03 | 0.38 ± 0.01 | |
P-value | 0.2037 | 0.2115 | 0.2499 | <.0001 | 0.8456 | 0.7406 | |
rs133498277 | CC(157) | 32.22 ± 0.35 | 1.80 ± 0.05 | 12.67 ± 0.18 | 29.71 ± 0.24A | 4.05 ± 0.03 | 0.39 ± 0.01 |
TT(23) | 31.57 ± 0.54 | 1.82 ± 0.08 | 12.59 ± 0.29 | 30.62 ± 0.39C | 4.06 ± 0.04 | 0.38 ± 0.02 | |
CT(134) | 32.44 ± 0.35 | 1.74 ± 0.05 | 12.47 ± 0.18 | 28.92 ± 0.24B | 4.05 ± 0.03 | 0.38 ± 0.01 | |
P-value | 0.1847 | 0.2131 | 0.3740 | <.0001 | 0.9503 | 0.8353 | |
rs41919984 | CC(157) | 31.54 ± 0.53 | 1.79 ± 0.07 | 12.64 ± 0.29 | 30.68 ± 0.38A | 4.06 ± 0.04 | 0.38 ± 0.02 |
TT(24) | 32.16 ± 0.34 | 1.80 ± 0.05 | 12.62 ± 0.18 | 29.75 ± 0.24C | 4.08 ± 0.03 | 0.39 ± 0.01 | |
TC(134) | 32.41 ± 0.34 | 1.73 ± 0.05 | 12.39 ± 0.17 | 28.88 ± 0.23B | 4.08 ± 0.03 | 0.39 ± 0.01 | |
P-value | 0.1507 | 0.2088 | 0.2673 | <.0001 | 0.8309 | 0.6460 | |
rs41919985 | AA(25) | 31.55 ± 0.53 | 1.8 ± 0.07 | 12.52 ± 0.29 | 30.59 ± 0.38A | 4.07 ± 0.04 | 0.38 ± 0.02 |
GG(157) | 32.16 ± 0.34 | 1.80 ± 0.05 | 12.61 ± 0.18 | 29.75 ± 0.24A | 4.08 ± 0.03 | 0.39 ± 0.01 | |
GA(133) | 32.41 ± 0.34 | 1.73 ± 0.05 | 12.41 ± 0.17 | 28.88 ± 0.23B | 4.08 ± 0.03 | 0.39 ± 0.01 | |
P-value | 0.1446 | 0.1888 | 0.3716 | <.0001 | 0.9818 | 0.6229 | |
rs41919986 | CC(155) | 32.11 ± 0.34 | 1.80 ± 0.05 | 12.67 ± 0.18 | 29.77 ± 0.24A | 4.05 ± 0.03 | 0.39 ± 0.01 |
TT(25) | 31.53 ± 0.53 | 1.81 ± 0.07 | 12.54 ± 0.29 | 30.60 ± 0.38A | 4.05 ± 0.04 | 0.38 ± 0.02 | |
CT(132) | 32.38 ± 0.35 | 1.74 ± 0.05 | 12.50 ± 0.18 | 28.88 ± 0.24B | 4.03 ± 0.03 | 0.38 ± 0.01 | |
P-value | 0.1502 | 0.1425 | 0.4945 | <.0001 | 0.7292 | 0.6757 | |
Locus | Genotypes | C14INDEX | C16INDEX | C18INDEX | SFA | UFA | SFA/UFA |
rs136947640 | CC(248) | 7.62 ± 0.26 | 5.15 ± 0.12 | 69.96 ± 0.52 | 61.45 ± 0.31 | 36.89 ± 0.28 | 1.70 ± 0.04 |
TT(2) | 6.69 ± 1.19 | 5.44 ± 0.54 | 71.10 ± 2.50 | 60.67 ± 1.52 | 37.49 ± 1.39 | 1.62 ± 0.20 | |
CT(64) | 7.62 ± 0.31 | 5.35 ± 0.14 | 70.06 ± 0.63 | 61.09 ± 0.38 | 37.08 ± 0.34 | 1.68 ± 0.05 | |
P-value | 0.7344 | 0.1582 | 0.8863 | 0.4488 | 0.7360 | 0.8360 | |
rs41919999 | CC(64) | 7.39 ± 0.31 | 5.27 ± 0.14 | 70.57 ± 0.63 | 61.22 ± 0.38 | 37.11 ± 0.35 | 1.67 ± 0.05 |
TT(88) | 7.84 ± 0.30 | 5.22 ± 0.14 | 70.18 ± 0.60 | 60.92 ± 0.36 | 37.43 ± 0.33 | 1.66 ± 0.05 | |
CT(162) | 7.73 ± 0.26 | 5.20 ± 0.12 | 70.13 ± 0.53 | 61.29 ± 0.31 | 36.96 ± 0.29 | 1.69 ± 0.04 | |
P-value | 0.2796 | 0.8450 | 0.7036 | 0.4242 | 0.2017 | 0.7246 | |
rs132865003 | CC(220) | 7.74 ± 0.26 | 5.16 ± 0.12 | 70.10 ± 0.51 | 61.31 ± 0.31 | 37.02 ± 0.28 | 1.69 ± 0.04 |
TT(10) | 7.36 ± 0.57 | 5.17 ± 0.26 | 70.04 ± 1.19 | 61.77 ± 0.72 | 36.54 ± 0.66 | 1.71 ± 0.10 | |
CT(85) | 7.60 ± 0.28 | 5.30 ± 0.13 | 70.22 ± 0.57 | 61.17 ± 0.34 | 37.06 ± 0.31 | 1.68 ± 0.05 | |
P-value | 0.6364 | 0.2951 | 0.9567 | 0.6591 | 0.7296 | 0.9378 | |
rs134340637 | AA(10) | 7.36 ± 0.57 | 5.17 ± 0.26 | 70.04 ± 1.19 | 61.77 ± 0.72 | 36.54 ± 0.66 | 1.71 ± 0.10 |
GG(220) | 7.74 ± 0.26 | 5.16 ± 0.12 | 70.10 ± 0.51 | 61.31 ± 0.31 | 37.02 ± 0.28 | 1.69 ± 0.04 | |
AG(85) | 7.60 ± 0.28 | 5.30 ± 0.13 | 70.22 ± 0.57 | 61.17 ± 0.34 | 37.06 ± 0.31 | 1.68 ± 0.05 | |
P-value | 0.6364 | 0.2951 | 0.9567 | 0.6591 | 0.7296 | 0.9378 | |
rs41919992 | CC(157) | 7.66 ± 0.27 | 5.30 ± 0.12a | 70.06 ± 0.55 | 61.03 ± 0.33A | 37.27 ± 0.30A | 1.67 ± 0.04 |
TT(24) | 7.50 ± 0.42 | 5.40 ± 0.19ab | 70.71 ± 0.87 | 60.33 ± 0.52A | 38.22 ± 0.48A | 1.60 ± 0.07 | |
CT(133) | 7.56 ± 0.28 | 5.08 ± 0.13b | 69.86 ± 0.55 | 61.82 ± 0.33B | 36.44 ± 0.30B | 1.72 ± 0.04 | |
P-value | 0.8491 | 0.0190 | 0.5297 | 0.0004 | <.0001 | 0.0612 | |
rs133498277 | CC(157) | 7.58 ± 0.27 | 5.31 ± 0.12a | 70.07 ± 0.54 | 61.05 ± 0.32A | 37.31 ± 0.29A | 1.67 ± 0.04 |
TT(23) | 7.42 ± 0.42 | 5.45 ± 0.19a | 70.84 ± 0.87 | 60.29 ± 0.53A | 38.25 ± 0.48A | 1.60 ± 0.07 | |
CT(134) | 7.48 ± 0.27 | 5.10 ± 0.12b | 69.81 ± 0.54 | 61.84 ± 0.32B | 36.46 ± 0.30B | 1.73 ± 0.04 | |
P-value | 0.8410 | 0.0178 | 0.4115 | 0.0004 | <.0001 | 0.0617 | |
rs41919984 | CC(157) | 7.53 ± 0.42 | 5.37 ± 0.19ab | 70.82 ± 0.86 | 60.27 ± 0.52A | 38.29 ± 0.47A | 1.60 ± 0.07a |
TT(24) | 7.77 ± 0.27 | 5.32 ± 0.12b | 70.24 ± 0.54 | 60.91 ± 0.32A | 37.40 ± 0.29A | 1.66 ± 0.04ab | |
TC(134) | 7.61 ± 0.27 | 5.08 ± 0.12a | 69.95 ± 0.53 | 61.77 ± 0.32B | 36.48 ± 0.29B | 1.72 ± 0.04b | |
P-value | 0.6745 | 0.0154 | 0.4795 | 0.0002 | <.0001 | 0.0450 | |
rs41919985 | AA(25) | 7.51 ± 0.41 | 5.38 ± 0.19ab | 70.97 ± 0.85 | 60.31 ± 0.51A | 38.23 ± 0.47A | 1.60 ± 0.07a |
GG(157) | 7.77 ± 0.27 | 5.32 ± 0.12b | 70.24 ± 0.54 | 60.91 ± 0.32A | 37.4 ± 0.29A | 1.66 ± 0.04ab | |
GA(133) | 7.61 ± 0.27 | 5.07 ± 0.12a | 69.93 ± 0.53 | 61.77 ± 0.32B | 36.47 ± 0.29B | 1.72 ± 0.04b | |
P-value | 0.6642 | 0.0122 | 0.3517 | 0.0002 | <.0001 | 0.0472 | |
rs41919986 | CC(155) | 7.61 ± 0.27 | 5.34 ± 0.12A | 70.09 ± 0.54 | 60.97 ± 0.32A | 37.37 ± 0.29A | 1.66 ± 0.04ab |
TT(25) | 7.43 ± 0.41 | 5.45 ± 0.19A | 70.92 ± 0.85 | 60.33 ± 0.51A | 38.22 ± 0.47A | 1.60 ± 0.07b | |
CT(132) | 7.49 ± 0.27 | 5.09 ± 0.12B | 69.71 ± 0.54 | 61.86 ± 0.32B | 36.41 ± 0.29B | 1.73 ± 0.04a | |
P-value | 0.7937 | 0.0074 | 0.2439 | 0.0001 | <.0001 | 0.0393 |
Notes: P-value refers to the results of the association analysis between each SNP and milk fatty acid traits. Different letter (small letters: P < 0.05; capital letters: P < 0.01) superscripts (adjusted value after correction for multiple testing) indicate significant differences among the genotypes