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. 2016 Jul 28;17:110. doi: 10.1186/s12863-016-0418-x

Table 4.

Associations of nine SNPs of the FASN gene with milk medium-chain fatty acids (MCFAs) in Chinese Holstein cattle (LSM ± SE)

Locus Genotypes C10:0 C12:0 C14:0 C14:1
rs136947640 CC(248) 2.13 ± 0.06 2.63 ± 0.08 9.55 ± 0.13 0.79 ± 0.03
TT(2) 2.23 ± 0.24 2.66 ± 0.32 8.92 ± 0.54 0.65 ± 0.16
CT(64) 2.09 ± 0.07 2.56 ± 0.09 9.42 ± 0.15 0.78 ± 0.04
P-value 0.6139 0.5290 0.2611 0.6836
rs41919999 CC(64) 2.13 ± 0.07AB 2.68 ± 0.09AB 9.64 ± 0.15A 0.76 ± 0.04
TT(88) 1.99 ± 0.07B 2.53 ± 0.09B 9.25 ± 0.14B 0.79 ± 0.04
CT(162) 2.15 ± 0.06A 2.73 ± 0.08A 9.52 ± 0.13A 0.80 ± 0.03
P-value 0.0012 0.0041 0.0071 0.6264
rs132865003 CC(220) 2.11 ± 0.06 2.68 ± 0.08 9.52 ± 0.13 0.80 ± 0.03
TT(10) 2.17 ± 0.12 2.72 ± 0.16 9.45 ± 0.26 0.75 ± 0.08
CT(85) 2.11 ± 0.06 2.68 ± 0.08 9.49 ± 0.14 0.78 ± 0.04
P-value 0.8601 0.9610 0.9217 0.7157
rs134340637 AA(10) 2.17 ± 0.12 2.72 ± 0.16 9.45 ± 0.26 0.75 ± 0.08
GG(220) 2.11 ± 0.06 2.68 ± 0.08 9.52 ± 0.13 0.80 ± 0.03
AG(85) 2.11 ± 0.06 2.68 ± 0.08 9.49 ± 0.14 0.78 ± 0.04
P-value 0.8601 0.9610 0.9217 0.7157
rs41919992 CC(157) 2.05 ± 0.06A 2.53 ± 0.08A 9.31 ± 0.13A 0.77 ± 0.04
TT(24) 2.06 ± 0.09AB 2.45 ± 0.12A 9.35 ± 0.20A 0.76 ± 0.06
CT(133) 2.20 ± 0.06B 2.74 ± 0.08B 9.75 ± 0.13B 0.79 ± 0.04
P-value 0.0013 <.0001 <.0001 0.6169
rs133498277 CC(157) 2.05 ± 0.06A 2.53 ± 0.08A 9.32 ± 0.13A 0.77 ± 0.04
TT(23) 2.07 ± 0.09AB 2.47 ± 0.12A 9.42 ± 0.20AB 0.75 ± 0.06
CT(134) 2.18 ± 0.06B 2.73 ± 0.08B 9.75 ± 0.13B 0.79 ± 0.04
P-value 0.0043 0.0003 <.0001 0.6826
rs41919984 CC(157) 2.06 ± 0.09AB 2.51 ± 0.11A 9.38 ± 0.19AB 0.76 ± 0.06
TT(24) 2.04 ± 0.06B 2.58 ± 0.08A 9.29 ± 0.13B 0.78 ± 0.04
TC(134) 2.19 ± 0.06A 2.81 ± 0.08B 9.74 ± 0.13A 0.80 ± 0.04
P-value 0.0010 <.0001 <.0001 0.6958
rs41919985 AA(25) 2.08 ± 0.09AB 2.54 ± 0.11A 9.46 ± 0.19AB 0.76 ± 0.06
GG(157) 2.04 ± 0.06B 2.58 ± 0.08A 9.28 ± 0.13B 0.78 ± 0.04
GA(133) 2.18 ± 0.06A 2.80 ± 0.08B 9.73 ± 0.13A 0.80 ± 0.04
P-value 0.0017 <.0001 <.0001 0.7268
rs41919986 CC(155) 2.03 ± 0.06A 2.54 ± 0.08A 9.36 ± 0.13A 0.77 ± 0.04
TT(25) 2.08 ± 0.09AB 2.50 ± 0.11A 9.50 ± 0.19AB 0.76 ± 0.06
CT(132) 2.17 ± 0.06B 2.74 ± 0.08B 9.78 ± 0.13B 0.79 ± 0.04
P-value 0.0015 0.0002 <.0001 0.7225
Locus Genotypes C16:0 C16:1 C18:0 C18:1n9c C18:2n6c CLA
rs136947640 CC(248) 32.30 ± 0.33 1.75 ± 0.05 12.59 ± 0.17 29.36 ± 0.22 4.03 ± 0.03A 0.38 ± 0.01
TT(2) 32.38 ± 1.52 1.86 ± 0.21 12.25 ± 0.85 30.18 ± 1.13 3.73 ± 0.13A 0.38 ± 0.05
CT(64) 32.17 ± 0.40 1.81 ± 0.06 12.54 ± 0.21 29.36 ± 0.28 4.12 ± 0.03B 0.40 ± 0.01
P-value 0.9155 0.3007 0.9028 0.7714 <.0001 0.3536
rs41919999 CC(64) 32.22 ± 0.40 1.79 ± 0.06 12.31 ± 0.21 29.43 ± 0.28 4.09 ± 0.03 0.40 ± 0.01
TT(88) 32.23 ± 0.38 1.77 ± 0.05 12.68 ± 0.20 29.82 ± 0.27 4.08 ± 0.03 0.38 ± 0.01
CT(162) 32.11 ± 0.34 1.76 ± 0.05 12.50 ± 0.17 29.36 ± 0.23 4.07 ± 0.03 0.39 ± 0.01
P-value 0.8921 0.7478 0.2182 0.0982 0.5542 0.4618
rs132865003 CC(220) 32.24 ± 0.33 1.75 ± 0.05 12.54 ± 0.17 29.44 ± 0.22 4.06 ± 0.03a 0.38 ± 0.01
TT(10) 32.65 ± 0.73 1.78 ± 0.10 12.43 ± 0.40 28.95 ± 0.54 4.00 ± 0.06ab 0.41 ± 0.02
CT(85) 32.19 ± 0.36 1.80 ± 0.05 12.46 ± 0.19 29.35 ± 0.25 4.12 ± 0.03b 0.40 ± 0.01
P-value 0.8073 0.4185 0.8504 0.6087 0.0128 0.1185
rs134340637 AA(10) 32.65 ± 0.73 1.78 ± 0.10 12.43 ± 0.40 28.95 ± 0.54 4.00 ± 0.06ab 0.41 ± 0.02
GG(220) 32.24 ± 0.33 1.75 ± 0.05 12.54 ± 0.17 29.44 ± 0.22 4.06 ± 0.03b 0.38 ± 0.01
AG(85) 32.19 ± 0.36 1.80 ± 0.05 12.46 ± 0.19 29.35 ± 0.25 4.12 ± 0.03a 0.40 ± 0.01
P-value 0.8073 0.4185 0.8504 0.6087 0.0128 0.1185
rs41919992 CC(157) 32.21 ± 0.35 1.79 ± 0.05 12.67 ± 0.18 29.68 ± 0.24A 4.05 ± 0.03 0.39 ± 0.01
TT(24) 31.62 ± 0.54 1.80 ± 0.08 12.69 ± 0.29 30.64 ± 0.39C 4.02 ± 0.04 0.38 ± 0.02
CT(133) 32.42 ± 0.35 1.73 ± 0.05 12.45 ± 0.18 28.89 ± 0.24B 4.05 ± 0.03 0.38 ± 0.01
P-value 0.2037 0.2115 0.2499 <.0001 0.8456 0.7406
rs133498277 CC(157) 32.22 ± 0.35 1.80 ± 0.05 12.67 ± 0.18 29.71 ± 0.24A 4.05 ± 0.03 0.39 ± 0.01
TT(23) 31.57 ± 0.54 1.82 ± 0.08 12.59 ± 0.29 30.62 ± 0.39C 4.06 ± 0.04 0.38 ± 0.02
CT(134) 32.44 ± 0.35 1.74 ± 0.05 12.47 ± 0.18 28.92 ± 0.24B 4.05 ± 0.03 0.38 ± 0.01
P-value 0.1847 0.2131 0.3740 <.0001 0.9503 0.8353
rs41919984 CC(157) 31.54 ± 0.53 1.79 ± 0.07 12.64 ± 0.29 30.68 ± 0.38A 4.06 ± 0.04 0.38 ± 0.02
TT(24) 32.16 ± 0.34 1.80 ± 0.05 12.62 ± 0.18 29.75 ± 0.24C 4.08 ± 0.03 0.39 ± 0.01
TC(134) 32.41 ± 0.34 1.73 ± 0.05 12.39 ± 0.17 28.88 ± 0.23B 4.08 ± 0.03 0.39 ± 0.01
P-value 0.1507 0.2088 0.2673 <.0001 0.8309 0.6460
rs41919985 AA(25) 31.55 ± 0.53 1.8 ± 0.07 12.52 ± 0.29 30.59 ± 0.38A 4.07 ± 0.04 0.38 ± 0.02
GG(157) 32.16 ± 0.34 1.80 ± 0.05 12.61 ± 0.18 29.75 ± 0.24A 4.08 ± 0.03 0.39 ± 0.01
GA(133) 32.41 ± 0.34 1.73 ± 0.05 12.41 ± 0.17 28.88 ± 0.23B 4.08 ± 0.03 0.39 ± 0.01
P-value 0.1446 0.1888 0.3716 <.0001 0.9818 0.6229
rs41919986 CC(155) 32.11 ± 0.34 1.80 ± 0.05 12.67 ± 0.18 29.77 ± 0.24A 4.05 ± 0.03 0.39 ± 0.01
TT(25) 31.53 ± 0.53 1.81 ± 0.07 12.54 ± 0.29 30.60 ± 0.38A 4.05 ± 0.04 0.38 ± 0.02
CT(132) 32.38 ± 0.35 1.74 ± 0.05 12.50 ± 0.18 28.88 ± 0.24B 4.03 ± 0.03 0.38 ± 0.01
P-value 0.1502 0.1425 0.4945 <.0001 0.7292 0.6757
Locus Genotypes C14INDEX C16INDEX C18INDEX SFA UFA SFA/UFA
rs136947640 CC(248) 7.62 ± 0.26 5.15 ± 0.12 69.96 ± 0.52 61.45 ± 0.31 36.89 ± 0.28 1.70 ± 0.04
TT(2) 6.69 ± 1.19 5.44 ± 0.54 71.10 ± 2.50 60.67 ± 1.52 37.49 ± 1.39 1.62 ± 0.20
CT(64) 7.62 ± 0.31 5.35 ± 0.14 70.06 ± 0.63 61.09 ± 0.38 37.08 ± 0.34 1.68 ± 0.05
P-value 0.7344 0.1582 0.8863 0.4488 0.7360 0.8360
rs41919999 CC(64) 7.39 ± 0.31 5.27 ± 0.14 70.57 ± 0.63 61.22 ± 0.38 37.11 ± 0.35 1.67 ± 0.05
TT(88) 7.84 ± 0.30 5.22 ± 0.14 70.18 ± 0.60 60.92 ± 0.36 37.43 ± 0.33 1.66 ± 0.05
CT(162) 7.73 ± 0.26 5.20 ± 0.12 70.13 ± 0.53 61.29 ± 0.31 36.96 ± 0.29 1.69 ± 0.04
P-value 0.2796 0.8450 0.7036 0.4242 0.2017 0.7246
rs132865003 CC(220) 7.74 ± 0.26 5.16 ± 0.12 70.10 ± 0.51 61.31 ± 0.31 37.02 ± 0.28 1.69 ± 0.04
TT(10) 7.36 ± 0.57 5.17 ± 0.26 70.04 ± 1.19 61.77 ± 0.72 36.54 ± 0.66 1.71 ± 0.10
CT(85) 7.60 ± 0.28 5.30 ± 0.13 70.22 ± 0.57 61.17 ± 0.34 37.06 ± 0.31 1.68 ± 0.05
P-value 0.6364 0.2951 0.9567 0.6591 0.7296 0.9378
rs134340637 AA(10) 7.36 ± 0.57 5.17 ± 0.26 70.04 ± 1.19 61.77 ± 0.72 36.54 ± 0.66 1.71 ± 0.10
GG(220) 7.74 ± 0.26 5.16 ± 0.12 70.10 ± 0.51 61.31 ± 0.31 37.02 ± 0.28 1.69 ± 0.04
AG(85) 7.60 ± 0.28 5.30 ± 0.13 70.22 ± 0.57 61.17 ± 0.34 37.06 ± 0.31 1.68 ± 0.05
P-value 0.6364 0.2951 0.9567 0.6591 0.7296 0.9378
rs41919992 CC(157) 7.66 ± 0.27 5.30 ± 0.12a 70.06 ± 0.55 61.03 ± 0.33A 37.27 ± 0.30A 1.67 ± 0.04
TT(24) 7.50 ± 0.42 5.40 ± 0.19ab 70.71 ± 0.87 60.33 ± 0.52A 38.22 ± 0.48A 1.60 ± 0.07
CT(133) 7.56 ± 0.28 5.08 ± 0.13b 69.86 ± 0.55 61.82 ± 0.33B 36.44 ± 0.30B 1.72 ± 0.04
P-value 0.8491 0.0190 0.5297 0.0004 <.0001 0.0612
rs133498277 CC(157) 7.58 ± 0.27 5.31 ± 0.12a 70.07 ± 0.54 61.05 ± 0.32A 37.31 ± 0.29A 1.67 ± 0.04
TT(23) 7.42 ± 0.42 5.45 ± 0.19a 70.84 ± 0.87 60.29 ± 0.53A 38.25 ± 0.48A 1.60 ± 0.07
CT(134) 7.48 ± 0.27 5.10 ± 0.12b 69.81 ± 0.54 61.84 ± 0.32B 36.46 ± 0.30B 1.73 ± 0.04
P-value 0.8410 0.0178 0.4115 0.0004 <.0001 0.0617
rs41919984 CC(157) 7.53 ± 0.42 5.37 ± 0.19ab 70.82 ± 0.86 60.27 ± 0.52A 38.29 ± 0.47A 1.60 ± 0.07a
TT(24) 7.77 ± 0.27 5.32 ± 0.12b 70.24 ± 0.54 60.91 ± 0.32A 37.40 ± 0.29A 1.66 ± 0.04ab
TC(134) 7.61 ± 0.27 5.08 ± 0.12a 69.95 ± 0.53 61.77 ± 0.32B 36.48 ± 0.29B 1.72 ± 0.04b
P-value 0.6745 0.0154 0.4795 0.0002 <.0001 0.0450
rs41919985 AA(25) 7.51 ± 0.41 5.38 ± 0.19ab 70.97 ± 0.85 60.31 ± 0.51A 38.23 ± 0.47A 1.60 ± 0.07a
GG(157) 7.77 ± 0.27 5.32 ± 0.12b 70.24 ± 0.54 60.91 ± 0.32A 37.4 ± 0.29A 1.66 ± 0.04ab
GA(133) 7.61 ± 0.27 5.07 ± 0.12a 69.93 ± 0.53 61.77 ± 0.32B 36.47 ± 0.29B 1.72 ± 0.04b
P-value 0.6642 0.0122 0.3517 0.0002 <.0001 0.0472
rs41919986 CC(155) 7.61 ± 0.27 5.34 ± 0.12A 70.09 ± 0.54 60.97 ± 0.32A 37.37 ± 0.29A 1.66 ± 0.04ab
TT(25) 7.43 ± 0.41 5.45 ± 0.19A 70.92 ± 0.85 60.33 ± 0.51A 38.22 ± 0.47A 1.60 ± 0.07b
CT(132) 7.49 ± 0.27 5.09 ± 0.12B 69.71 ± 0.54 61.86 ± 0.32B 36.41 ± 0.29B 1.73 ± 0.04a
P-value 0.7937 0.0074 0.2439 0.0001 <.0001 0.0393

Notes: P-value refers to the results of the association analysis between each SNP and milk fatty acid traits. Different letter (small letters: P < 0.05; capital letters: P < 0.01) superscripts (adjusted value after correction for multiple testing) indicate significant differences among the genotypes