. 2016 Jul 28;17:110. doi: 10.1186/s12863-016-0418-x

Table 5.

Associations of SNPs of PPARGC1A, ABCG2 and IGF1 genes with milk medium-chain fatty acids (MCFAs) in Chinese Holstein cattle (LSM ± SE)

Gene	Locus	Genotypes	C10:0	C12:0	C14:0	C14:1
PPARGC1A	rs109579682	CC(27)	2.10 ± 0.06^ab	2.66 ± 0.07^a	9.50 ± 0.13^a	0.77 ± 0.03
		TT(170)	1.94 ± 0.08^b	2.42 ± 0.11^b	9.19 ± 0.19^ab	0.79 ± 0.05
		CT(147)	2.13 ± 0.06^a	2.62 ± 0.08^ab	9.30 ± 0.13^b	0.78 ± 0.03
		P-value	0.0251	0.034	0.0188	0.8281
ABCG2	rs137757790	AA(115)	2.13 ± 0.06	2.67 ± 0.08	9.58 ± 0.13^A	0.78 ± 0.04
		CC(85)	2.06 ± 0.06	2.58 ± 0.08	9.21 ± 0.14^B	0.76 ± 0.04
		CA(145)	2.12 ± 0.06	2.64 ± 0.08	9.50 ± 0.13^A	0.78 ± 0.03
		P-value	0.2206	0.3385	0.0026	0.7772
IGF1	rs109763947	CC(58)	2.06 ± 0.07^a	2.64 ± 0.09	9.47 ± 0.15	0.77 ± 0.04
		TT(100)	2.19 ± 0.06^b	2.72 ± 0.08	9.57 ± 0.14	0.77 ± 0.04
		CT(187)	2.10 ± 0.06^ab	2.60 ± 0.07	9.42 ± 0.13	0.78 ± 0.03
		P-value	0.0342	0.0764	0.2805	0.9454
Gene	Locus	Genotypes	C16:0	C16:1	C18:0	C18:1n9c	C18:2n6c	CLA
PPARGC1A	rs109579682	CC(27)	32.44 ± 0.33	1.71 ± 0.05^a	12.61 ± 0.17	29.19 ± 0.22^A	4.07 ± 0.03	0.39 ± 0.01
		TT(170)	32.40 ± 0.51	1.82 ± 0.07^ab	12.59 ± 0.27	30.08 ± 0.36^B	4.08 ± 0.04	0.37 ± 0.02
		CT(147)	31.99 ± 0.34	1.79 ± 0.05^b	12.59 ± 0.17	29.74 ± 0.23^B	4.07 ± 0.03	0.38 ± 0.01
		P-value	0.1541	0.0401	0.9845	0.0015	0.9515	0.6788
ABCG2	rs137757790	AA(115)	32.45 ± 0.35	1.72 ± 0.05	12.52 ± 0.18	29.12 ± 0.24^A	4.05 ± 0.03	0.37 ± 0.01
		CC(85)	31.99 ± 0.37	1.71 ± 0.05	12.79 ± 0.19	29.91 ± 0.26^B	4.08 ± 0.03	0.38 ± 0.01
		CA(145)	32.33 ± 0.33	1.76 ± 0.05	12.48 ± 0.17	29.50 ± 0.22^AB	4.07 ± 0.03	0.39 ± 0.01
		P-value	0.3251	0.3431	0.1475	0.0048	0.6085	0.2071
IGF1	rs109763947	CC(58)	32.29 ± 0.39	1.81 ± 0.05	12.44 ± 0.20	29.42 ± 0.27^AB	4.08 ± 0.03^A	0.39 ± 0.01
		TT(100)	32.52 ± 0.36	1.7 ± 0.05	12.62 ± 0.18	29.02 ± 0.25^B	3.99 ± 0.03^B	0.38 ± 0.01
		CT(187)	32.19 ± 0.33	1.73 ± 0.05	12.57 ± 0.16	29.70 ± 0.22^A	4.10 ± 0.03^A	0.38 ± 0.01
		P-value	0.4406	0.0797	0.6613	0.0024	<.0001	0.5835
Gene	Locus	Genotypes	C14INDEX	C16INDEX	C18INDEX	SFA	UFA	SFA/UFA
PPARGC1A	rs109579682	CC(27)	7.50 ± 0.26	5.03 ± 0.12^A	69.81 ± 0.51	61.62 ± 0.30^A	36.75 ± 0.28^A	1.70 ± 0.04
		TT(170)	7.89 ± 0.40	5.33 ± 0.18^B	70.52 ± 0.82	60.75 ± 0.49^B	37.74 ± 0.45^B	1.64 ± 0.07
		CT(147)	7.75 ± 0.27	5.33 ± 0.12^B	70.24 ± 0.53	60.92 ± 0.32^B	37.38 ± 0.29^B	1.66 ± 0.04
		P-value	0.3099	0.0010	0.4283	0.0065	0.0038	0.2931
ABCG2	rs137757790	AA(115)	7.51 ± 0.28	5.05 ± 0.13	69.96 ± 0.55	61.64 ± 0.33^A	36.67 ± 0.30^a	1.71 ± 0.04
		CC(85)	7.62 ± 0.29	5.10 ± 0.13	70.00 ± 0.59	60.81 ± 0.35^B	37.45 ± 0.32^b	1.65 ± 0.05
		CA(145)	7.57 ± 0.26	5.19 ± 0.12	70.29 ± 0.52	61.33 ± 0.31^AB	37.11 ± 0.28^ab	1.68 ± 0.04
		P-value	0.8925	0.3350	0.7065	0.0343	0.0266	0.4267
IGF1	rs109763947	CC(58)	7.50 ± 0.31	5.32 ± 0.14^a	70.26 ± 0.62	61.14 ± 0.37^A	37.10 ± 0.34^AB	1.67 ± 0.05
		TT(100)	7.5 ± 0.28	4.98 ± 0.13^b	69.68 ± 0.56	61.88 ± 0.33^B	36.47 ± 0.30^B	1.73 ± 0.04
		CT(187)	7.62 ± 0.26	5.13 ± 0.12^ab	70.31 ± 0.51	61.10 ± 0.30^A	37.31 ± 0.28^A	1.66 ± 0.04
		P-value	0.8036	0.0239	0.3301	0.009	0.0023	0.1970

Notes: P-value refers to the results of the association analysis between each SNP and milk fatty acid traits. Different letter (small letters: P < 0.05; capital letters: P < 0.01) superscripts (adjusted value after correction for multiple testing) indicate significant differences among the genotypes