Table 9.
Haplotype associations of the eight SNPs in FASN with milk production traits in Chinese Holstein cattle (LSM ± SE)
| FASN haplotypes | C10:0 | C12:0 | C14:0 | C14:1 | C16:0 | C16:1 |
| H1H1(88) | 2.02 ± 0.05a | 2.54 ± 0.07A | 9.27 ± 0.12A | 0.78 ± 0.03 | 32.45 ± 0.33 | 1.79 ± 0.05 |
| H2H1(103) | 2.23 ± 0.05b | 2.81 ± 0.06B | 9.75 ± 0.11B | 0.80 ± 0.03 | 32.41 ± 0.29 | 1.72 ± 0.04 |
| H2H2(24) | 2.12 ± 0.09b | 2.54 ± 0.12B | 9.53 ± 0.20AB | 0.76 ± 0.06 | 31.54 ± 0.53 | 1.79 ± 0.07 |
| H2H3(28) | 2.16 ± 0.08b | 2.80 ± 0.10B | 9.95 ± 0.17B | 0.76 ± 0.05 | 32.90 ± 0.48 | 1.76 ± 0.07 |
| H3H1(57) | 2.09 ± 0.06b | 2.60 ± 0.08B | 9.22 ± 0.14A | 0.77 ± 0.04 | 31.84 ± 0.37 | 1.82 ± 0.05 |
| H3H3(10) | 2.16 ± 0.13b | 2.72 ± 0.17B | 9.43 ± 0.29AB | 0.74 ± 0.08 | 32.59 ± 0.77 | 1.80 ± 0.11 |
| P-value | 0.0204 | 0.0057 | 0.0001 | 0.9268 | 0.2257 | 0.4522 |
| FASN haplotypes | C18:0 | C18:1n9c | C18:2n6c | CLA | C14index | C16index |
| H1H1(88) | 12.69 ± 0.18 | 29.59 ± 0.24AC | 4.07 ± 0.03 | 0.38 ± 0.01 | 7.79 ± 0.26 | 5.26 ± 0.12 |
| H2H1(103) | 12.51 ± 0.16 | 28.89 ± 0.21BC | 4.04 ± 0.02 | 0.37 ± 0.01 | 7.61 ± 0.23 | 5.03 ± 0.10 |
| H2H2(24) | 12.62 ± 0.29 | 30.56 ± 0.38A | 4.05 ± 0.04 | 0.37 ± 0.02 | 7.46 ± 0.42 | 5.36 ± 0.19 |
| H2H3(28) | 12.22 ± 0.26 | 28.31 ± 0.34B | 4.14 ± 0.04 | 0.40 ± 0.02 | 7.16 ± 0.37 | 5.08 ± 0.17 |
| H3H1(57) | 12.65 ± 0.20 | 29.85 ± 0.27A | 4.11 ± 0.03 | 0.39 ± 0.01 | 7.68 ± 0.29 | 5.45 ± 0.13 |
| H3H3(10) | 12.38 ± 0.41 | 28.91 ± 0.55ABC | 4.03 ± 0.06 | 0.40 ± 0.03 | 7.23 ± 0.60 | 5.25 ± 0.27 |
| P-value | 0.6616 | <.0001 | 0.0792 | 0.4543 | 0.7264 | 0.0548 |
| FASN Haplotypes | C18index | SFA | UFA | SFA/UFA | ||
| H1H1(88) | 69.95 ± 0.53 | 61.15 ± 0.32AB | 37.20 ± 0.29AB | 1.68 ± 0.04 | ||
| H2H1(103) | 69.71 ± 0.47 | 61.87 ± 0.29A | 36.40 ± 0.26A | 1.73 ± 0.04 | ||
| H2H2(24) | 70.75 ± 0.86 | 60.39 ± 0.52AB | 38.15 ± 0.47B | 1.61 ± 0.07 | ||
| H2H3(28) | 69.85 ± 0.77 | 62.20 ± 0.46AB | 35.99 ± 0.42A | 1.75 ± 0.06 | ||
| H3H1(57) | 70.25 ± 0.60 | 60.69 ± 0.36B | 37.55 ± 0.33B | 1.64 ± 0.05 | ||
| H3H3(10) | 70.11 ± 1.24 | 61.75 ± 0.74AB | 36.54 ± 0.68AB | 1.71 ± 0.10 | ||
| P-value | 0.8619 | 0.0025 | <.0001 | 0.2846 | ||
Notes: P-value refers to the results of the association analysis between each haplotype and milk fatty acid traits. Different letter (small letters: P < 0.05; capital letters: P < 0.01) superscripts (adjusted value after correction for multiple testing) indicate significant differences among the haplotypes. H1 = TCGCCTGC, H2 = CCGTTCAT, H3 = CTACCTGC