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. 2016 Jan 11;50(4):318–321. doi: 10.4132/jptm.2015.10.17

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© 2016 The Korean Society of Pathologists/The Korean Society for Cytopathology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Representative microscopic findings of mixed adenoneuroendocrine carcinoma with trilineage histologic differentiation. (A) Moderately differentiated adenocarcinoma admixed with large cell neuroendocrine carcinoma (NEC). (B) The NEC component demonstrates positive staining for chromogranin A, whereas the adenocarcinoma component shows negativity. (C) Squamous cell carcinoma (SqCC) component admixed with the NEC component, and (D) the NEC component presented positivity for chromogranin A, but not the SqCC component. (E) The cells with squamous cell differentiation are identified by expression of p63. (F) Metastasis of only the adenocarcinoma component to the gastric regional lymph nodes.