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NR4A2 reversed Notch1-induced cell growth arrest. (A), MTT assay showed that Notch1 activation in Hela-ICN1 reduced cell growth, with an inhibitory rate of 52%. The co-expression of NR4A2 and ICN1 reduced the Notch1-induced inhibitory rate to 44%, Asterisk (*) shows P values< 0.05. (B), NR4A2 via wetsern blot assay reduced the increase of Notch1-induced p63, with no effects on p21 and c-Myc.
