Table 1.

Summary of differentially expressed genes associated with peptidase activity (GO:0008233) and showed positive associations to cancer invasiveness and metastasis in the transcriptome of urothelial carcinoma of urinary bladder (GSE31684).

6.5	Comparing T2-4 to Ta-T1		Comparing Meta. to Non-Meta.#		Gene Symbol	Gene Title	Molecular Function
	log ratio	p-value	log ratio	p-value
1555229_a_at	1.4602	0.0001	0.9181	0.0013	C1S	complement component 1; s subcomponent	calcium ion binding, complement component C1s activity, hydrolase activity, metal ion binding, peptidase activity, rhodopsin-like receptor activity, serine-type endopeptidase activity, serine-type endopeptidase inhibitor activity, serine-type peptidase activity
201117_s_at	1.081	0.0048	0.8652	0.0037	CPE	carboxypeptidase E	carboxypeptidase A activity, carboxypeptidase E activity, carboxypeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, zinc ion binding
205825_at	0.3938	0.0087	0.3003	0.0088	PCSK1	proprotein convertase subtilisin/kexin type 1	calcium ion binding, hydrolase activity, peptidase activity, proprotein convertase 1 activity, serine-type endopeptidase activity, subtilase activity
209955_s_at	1.5836	<0.0001	0.5783	0.0051	FAP	fibroblast activation protein; alpha	dipeptidyl-peptidase IV activity, hydrolase activity, metalloendopeptidase activity, peptidase activity, prolyl oligopeptidase activity, protein dimerization activity, protein homodimerization activity, serine-type endopeptidase activity, serine-type peptidase activity
213652_at	0.5635	<0.0001	0.3841	0.0002	PCSK5	proprotein convertase subtilisin/kexin type 5	hydrolase activity, peptidase activity, serine-type endopeptidase activity, subtilase activity
214913_at	0.2909	0.0009	0.2036	0.0025	ADAMTS3	ADAM metallopeptidase with thrombospondin type 1 motif; 3	heparin binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding
227860_at	0.6945	<0.0001	0.4549	0.0001	CPXM1	carboxypeptidase X (M14 family); member 1	carboxypeptidase A activity, carboxypeptidase E activity, carboxypeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, zinc ion binding
235874_at	0.3376	0.0001	0.2276	0.0007	PRSS35	protease; serine; 35	peptidase activity, serine-type endopeptidase activity
1558117_s_at	-0.5337	0.0039	-0.4279	0.0026	USP31	ubiquitin specific peptidase 31	cysteine-type peptidase activity, hydrolase activity, peptidase activity, ubiquitin thiolesterase activity
210693_at	-0.376	<0.0001	-0.1507	0.001	SPPL2B	signal peptide peptidase-like 2B	aspartic-type endopeptidase activity, hydrolase activity, peptidase activity
220390_at	-0.1759	0.0032	-0.1536	0.0007	AGBL2	ATP/GTP binding protein-like 2	carboxypeptidase A activity, carboxypeptidase activity, hydrolase activity, metal ion binding, metallopeptidase activity, peptidase activity, zinc ion binding
239272_at	-1.4769	<0.0001	-0.7875	0.0022	MMP28	matrix metallopeptidase 28	calcium ion binding, hydrolase activity, metal ion binding, metalloendopeptidase activity, metallopeptidase activity, peptidase activity, zinc ion binding

#, Meta., distal metastasis developed during follow-up; Non-Meta.: no metastatic event developed.