Table 2.

Correlations between C1s expression and other important clinicopathological parameters in urothelial carcinomas.

Parameter	Category	Upper Urinary Tract Urothelial Carcinoma				Urinary Bladder Urothelial Carcinoma
		Case No.	C1s Expression		p-value	Case No.	C1s Expression		p-value
			Low	High			Low	High
Gender	Male	158	74	84	0.277	216	112	104	0.251
	Female	182	96	86		79	35	44
Age (years)	< 65	138	67	71	0.659	121	58	63	0.587
	≥ 65	202	103	99		174	89	85
Tumor location	Renal pelvis	141	64	77	0.228	-	-	-	-
	Ureter	150	77	73		-	-	-	-
	Renal pelvis & ureter	49	29	20		-	-	-	-
Multifocality	Single	278	135	143	0.261	-	-	-	-
	Multifocal	62	35	27		-	-	-	-
Primary tumor (T)	Ta	89	64	25	<0.001*	84	70	14	<0.001*
	T1	92	67	25		88	50	38
	T2-T4	159	39	120		123	27	96
Nodal metastasis	Negative (N0)	312	163	149	0.006*	266	142	124	<0.001*
	Positive (N1-N3)	28	7	21		29	5	24
Histological grade	Low grade	56	40	16	<0.001*	56	45	11	<0.001*
	High grade	284	130	154		239	102	137
Vascular invasion	Absent	234	147	87	<0.001*	246	136	110	<0.001*
	Present	106	23	83		49	11	38
Perineural invasion	Absent	321	165	156	0.034*	275	142	133	0.021*
	Present	19	5	14		20	5	15
Mitotic rate (per 10 high power fields)	< 10	173	96	77	0.039*	139	82	57	0.003*
	>= 10	167	74	93		156	65	91

* Statistically significant.