Table 3.

Univariate log-rank and multivariate analyses for Disease-specific and Metastasis-free Survivals in upper urinary tract urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific Survival					Metastasis-free Survival
			Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
			No. of event	p-value	R.R.	95% C.I.	p-value	No. of event	p-value	R.R.	95% C.I.	p-value
Gender	Male	158	28	0.8286	-	-	-	32	0.7904	-	-	-
	Female	182	33		-	-	-	38		-	-	-
Age (years)	< 65	138	26	0.9943	-	-	-	30	0.8470	-	-	-
	≥ 65	202	35		-	-	-	40		-	-	-
Tumor side	Right	177	34	0.7366	-	-	-	38	0.3074	-	-	-
	Left	154	26		-	-	-	32		-	-	-
	Bilateral	9	1		-	-	-	0		-	-	-
Tumor location	Renal pelvis	141	24	0.0079*	1	-	0.997	31	0.0659	-	-	-
	Ureter	150	22		0.859	0.462-1.598		25		-	-	-
	Renal pelvis & ureter	49	15		1.334	0.370-4.805		14		-	-	-
Multifocality	Single	273	48	0.0026*	1	-	0.005*	52	0.0127*	1	-	<0.001*
	Multifocal	62	18		3.026	1.400-6.540		18		2.517	1.453-4.360
Primary tumor (T)	Ta	89	2	<0.0001*	1	-	0.015*	4	<0.0001*	1	-	0.180
	T1	92	9		5.281	0.834-33.444		15		2.807	0.865-9.110
	T2-T4	159	50		7.405	1.286-42.636		51		2.657	0.823-8.582
Nodal metastasis	Negative (N0)	312	42	<0.0001*	1	-	<0.001*	55	<0.0001*	1	-	<0.001*
	Positive (N1-N3)	28	19		5.707	3.085-10.558		15		3.135	1.698-5.788
Histological grade	Low grade	56	4	0.0215*	1	-	0.029*	3	0.0027*	1	-	0.020*
	High grade	284	57		3.507	1.137-10.814		67		4.259	1.251-14.496
Vascular invasion	Absent	234	24	<0.0001*	1	-	0.160	26	<0.0001*	1	-	0.003*
	Present	106	37		1.531	0.845-2.774		44		2.459	1.347-4.487
Perineural invasion	Absent	321	50	<0.0001*	1	-	<0.001*	61	<0.0001*	1	-	0.009*
	Present	19	11		4.045	1.931-8.476		9		2.712	1.289-5.708
Mitotic rate (per 10 high power fields)	< 10	173	27	0.167	-	-		30	0.0823	-	-
	>= 10	167	34		-	-		40		-	-
C1s expression	Low	170	8	<0.0001*	1	-	<0.001*	18	<0.0001*	1	-	0.006*
	High	170	53		1.755	1.385-2.225		52		1.482	1.117-1.967

* Statistically significant