Table 4.

Univariate log-rank and multivariate analyses for Disease-specific and Metastasis-free Survivals in urinary bladder urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific Survival					Metastasis-free Survival
			Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
			No. of event	p-value	R.R.	95% C.I.	p-value	No. of event	p-value	R.R.	95% C.I.	p-value
Gender	Male	216	41	0.4446	-	-	-	60	0.2720	-	-	-
	Female	79	11		-	-	-	16		-	-	-
Age (years)	< 65	121	17	0.1136	-	-	-	31	0.6875	-	-	-
	≥ 65	174	35		-	-	-	45		-	-	-
Primary tumor (T)	Ta	84	1	<0.0001*	1	-	0.006*	4	<0.0001*	1	-	0.019*
	T1	88	9		2.865	1.299-6.329		23		4.177	1.216-14.343
	T2-T4	123	42		11.764	1.344-100		49		5.208	1.487-18.234
Nodal metastasis	Negative (N0)	266	41	0.0002*	1	-	0.859	61	<0.0001*	1	-	0.099
	Positive (N1-N3)	29	11		1.066	0.524-2.169		15		1.689	0.906-3.149
Histological grade	Low grade	56	2	0.0013*	1	-	0.886	5	0.0007*	1	-	0.685
	High grade	239	50		0.892	0.187-4.264		71		0.799	0.269-2.368
Vascular invasion	Absent	246	37	0.0024*	1	-	0.119	54	0.0001*	1	-	0.977
	Present	49	15		0.574	0.286-1.154		22		0.991	0.534-1.838
Perineural invasion	Absent	275	44	0.0001*	1	-	0.018*	66	0.0007*	1	-	0.112
	Present	20	8		2.805	1.197-6.574		10		1.834	0.868-3.878
Mitotic rate (per 10 high power fields)	< 10	139	12	<0.0001*	1	-	0.011*	23	<0.0001*	1	-	0.022*
	>= 10	156	40		2.379	1.220-4.640		53		1.828	1.092-3.059
C1s expression	Low	147	3	<0.0001*	1	-	<0.001*	16	<0.0001*	1	-	<0.001*
	High	148	49		11.441	3.478-37.628		60		2.984	1.661-5.361

* Statistically significant