Table 2.
Selected genes with promotor hypermethylation and their clinical correlations in ovarian carcinomas.
| Genes | Clinical correlations | Ref(s). |
|---|---|---|
| RASSF1A | Detection of OC | 81, 82 |
| BRCA1 | Detection of OC; poor prognosis; improved chemotherapy response | 81,83,84 |
| APC | Serum/ascites diagnosis of OC | 81,83 |
| MGMT | Detection of OC; improved chemotherapy response | 83,85 |
| hMLH1 | Poor prognosis; improved chemotherapy response | 86-88 |
| HOXA9 | Detection of OC | 89 |
| OPCML | Detection of OC | 90 |
| SFRP-1, -2, -4, -5 | Detection of OC; Cancer recurrence; Poor prognosis | 91 |
| FZD4, DVL1, NFATC3, ROCK1, LRP5, AXIN1, and NKD1 | Poor prognosis | 92 |
| FBXO32 | Poor prognosis | 93 |
| HOXA11 | Poor clinical outcome. | 94 |
| FANCF | Cisplatin resistance | 95 |
Abbreviations: OC=ovarian carcinoma.