Table 5.
Differences in overrepresented proteins between African-American and Caucasian American tumors.
| Protein Class, Gene Ontology Molecular Function, or Gene Ontology Biological Process | Fold Enrichment | Q-value |
|---|---|---|
| *Actin binding motor protein (Cytoskeletal Protein) | 4.63 | 1.51E-04 |
| *Extracellular matrix structural protein (Extracellular Matrix Protein) | 3.42 | 1.07E-02 |
| *Complement component (Defense/Immunity Protein) | 4.08 | 1.16E-02 |
| *mRNA processing factor (Nucleic Acid Binding) | 2.4 | 3.04E-02 |
| *Ubiquitin-protein ligase (Ligase) | < 0.2 | 4.29E-02 |
| *Calcium ion binding (Binding) | 2.16 | 2.27E-05 |
| *Calmodulin binding (Binding) | 2.46 | 6.48E-05 |
| *Hydro-lyase activity (Catalytic Activity) | 4.25 | 3.17E-03 |
| *Peroxidase activity (Catalytic Activity) | > 5 | 6.10E-03 |
| *mRNA binding (Binding) | 2.69 | 7.29E-03 |
| *Extracellular matrix structural constituent (Structural Molecule Activity) | 3.42 | 8.90E-03 |
| *Peptidase inhibitor activity (Catalytic Activity) | 2.23 | 1.41E-02 |
| *Muscle contraction (Multicellular Organismal Process) | 2.72 | 7.15E-05 |
| *Cell adhesion (Biological Adhesion) | 1.77 | 6.48E-03 |
| *Regulation of liquid surface tension (Biological Regulation) | 4.03 | 7.25E-03 |
| *Regulation of catalytic activity (Biological Regulation) | 1.54 | 7.42E-03 |
| *RNA splicing, via transesterification reactions (Metabolic Process) | 2.76 | 9.74E-03 |
| *RNA splicing (Metabolic Process) | 2.7 | 1.33E-02 |
| *Regulation of molecular function (Biological Regulation) | 1.5 | 1.59E-02 |
| *System process (Multicellular Organismal Process) | 1.45 | 2.33E-02 |
| *Homeostatic process (Biological Regulation) | 2.24 | 2.87E-02 |
| *Oxidative phosphorylation (Metabolic Process) | 3.72 | 3.01E-02 |
| *Segment specification (Developmental Process) | < 0.2 | 4.22E-02 |
| †Anion channel (Transporter) | > 5 | 4.63E-02 |
| †Oxidase (Oxidoreductase) | 2.59 | 3.07E-02 |
| †Translation initiation factor (Nucleic Acid Binding) | 3.76 | 6.94E-03 |
| †Translation initiation factor activity (Binding) | 3.29 | 2.77E-03 |
| †Anion channel activity (Transporter Activity) | > 5 | 1.52E-02 |
| †Transferase activity, transferring acyl groups (Catalytic Activity) | 2.38 | 2.13E-02 |
| †Aminoacyl-tRNA ligase activity (Catalytic Activity) | > 5 | 3.10E-02 |
| †Cellular amino acid metabolic process (Metabolic Process) | 2.42 | 4.57E-04 |
| †Purine nucleobase metabolic process (Metabolic Process) | 3.43 | 3.74E-03 |
| †Response to toxic substance (Response to Stimulus) | 3.8 | 2.44E-02 |
Q-values have been adjusted using a Bonferroni correction. *Overrepresented in AA but not CA tumors. † Overrepresented in CA but not AA tumors.