Table 2.

Correlations between THBS2 Expression and other important clinicopathological parameters in urothelial carcinomas.

Parameter	Category	Upper Urinary Tract Urothelial Carcinoma				Urinary Bladder Urothelial Carcinoma
		Case No.	THBS2 Expression		p-value	Case No.	THBS2 Expression		p-value
			Low	High			Low	High
Gender&	Male	158	75	83	0.384	216	110	106	0.534
	Female	182	95	87		79	37	42
Age (years)#		340	65.94+/-10.01	65.22+/-9.69	0.214	295	66.04+/-12.67	66.05+/-11.78	0.704
Tumor location&	Renal pelvis	141	70	71	0.685	-	-	-	-
	Ureter	150	78	72		-	-	-	-
	Renal pelvis & ureter	49	22	27		-	-	-	-
Multifocality&	Single	278	142	136	0.339	-	-	-	-
	Multifocal	62	28	34		-	-	-	-
Primary tumor (pT) &	pTa	89	63	26	<0.001*	84	68	16	<0.001*
	pT1	92	50	42		88	46	42
	pT2-pT4	159	57	102		123	33	90
Nodal metastasis&	Negative (pN0)	312	163	149	<0.001*	266	141	125	0.001*
	Positive (pN1-pN3)	28	7	21		29	6	23
Histological grade &	Low grade	56	34	22	0.079	56	44	12	0.001*
	High grade	284	136	148		239	103	136
Vascular invasion&	Absent	234	132	102	<0.001*	246	134	112	<0.001*
	Present	106	38	68		49	13	36
Perineural invasion&	Absent	321	166	155	0.009*	275	141	134	0.066
	Present	19	4	15		20	6	14
Mitotic rate (per 10 high power fields)#		340	11.59+/-12.31	13.02+/-12.24	0.072	295	12.10+/-14.67	16.70+/-13.03	<0.001*

&, Chi-Square test; #, Mann-Whitney U test; * Statistically significant.