Table 4.

Univariate log-rank and multivariate analyses for Disease-specific and Metastasis-free Survivals in urinary bladder urothelial carcinoma.

Parameter	Category	Case No.	Disease-specific Survival					Metastasis-free Survival
			Univariate analysis		Multivariate analysis			Univariate analysis		Multivariate analysis
			No. of event	p-value	R.R.	95% C.I.	p-value	No. of event	p-value	R.R.	95% C.I.	p-value
Gender	Male	216	41	0.4906	-	-	-	61	0.2745	-	-	-
	Female	79	11		-	-	-	16		-	-	-
Age (years)	< 65	121	17	0.1315	-	-	-	32	0.8786	-	-	-
	≥ 65	174	35		-	-	-	45
Primary tumor (pT)	pTa	84	1	<0.0001*	1	-	<0.001*	4	<0.0001*	1	-	0.023*
	pT1	88	9		4.203	0.463-38.147		23		3.326	0.998-11.080
	pT2-pT4	123	42		18.697	2.142-163.230		50		5.159	1.528-17.418
Nodal metastasis	Negative (pN0)	266	41	0.0001*	1	-	0.550	61	<0.0001*	1	-	0.021*
	Positive (pN1-pN3)	29	11		1.242	0.610-2.530		16		2.050	1.114-3.773
Histological grade	Low grade	56	2	0.0016*	1	-	0.854	5	0.0007*	1	-	0.924
	High grade	239	50		1.158	0.243-5.518		72		1.052	0.367-3.015
Vascular invasion	Absent	246	37	0.0010*	1	-	0.181	54	<0.0001*	1	-	0.665
	Present	49	15		0.629	0.319-1.240		23		1.141	0.630-2.063
Perineural invasion	Absent	275	44	<0.0001*	1	-	0.009*	67	0.0003*	1	-	0.085
	Present	20	8		3.004	1.313-6.874		10		1.886	0.916-3.881
Mitotic rate (per 10 high power fields)	< 10	139	12	0.0001*	1	-	0.037*	23	0.0002*	1	-	0.086
	>= 10	156	40		2.054	1.044-4.039		54		1.572	0.938-2.635
THBS2 expression	Low	147	10	<0.0001*	1	-	0.033*	18	<0.0001*	1	-	0.004*
	High	148	42		2.204	1.065-4.562		59		2.275	1.307-3.960

* Statistically significant.