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. 2016 Jul 26;3(1):e000096. doi: 10.1136/bmjgast-2016-000096

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Compensatory mechanism of miRNA level regulation between tissues. (A) In physiological state, circulating miRNA plays a role in interorgan communications and help maintain balance in intracellular levels of miRNA. (B) Insufficient endogenous miRNA production in target tissue may result in a compensatory increase in production of same miRNA in other distant tissues and its subsequent release into circulation. (C) Increased intracellular levels in target cells may result in deliberate secretion of the miRNA by the cells into interstitial fluid. This would restore normal intracellular miRNA levels, while increasing the circulating levels. miRNA, microRNA.