Table 1.
Pharmacokinetic studies in the four decades
| Age group | Number of studies (number of cannula studies) |
Number of patients |
||||||
|---|---|---|---|---|---|---|---|---|
| 1976–1985 | 1986–1995 | 1996–2005 | 2006–2015 | 1976–1985 | 1986–1995 | 1996–2005 | 2006–2015 | |
| Neonates | 9 (1) | 18 (3) | 18 (4) | 8 (4) | 188 | 385 | 423 | 231 |
| Infants | 12 (3) | 6 (2) | 17 (6) | 11 (3) | 250 | 162 | 376 | 467 |
| Children | 20 (13) | 61 (20) | 102 (36) | 99 (32) | 301 | 1011 | 2826 | 5466 |
| Adolescents | 1 (1) | 4 (2) | 3 (1) | 11 (4) | 9 | 36 | 107 | 328 |
| Mixed age | 10 (2) | 16 (6) | 61 (17) | 62 (22) | 297 | 376 | 2468 | 3391 |
| Total | 52 (20) | 105 (33) | 201 (64) | 191 (68) | 748 | 1970 | 6200 | 9883 |