Table 4.

Total blood volume for all samples per paediatric patient

Age group	Total volume of blood samples (mL)
	1976–1985 Median [IQR] (range)	1986–1995 Median [IQR] (range)	1996–2005 Median [IQR] (range)	2006–2015 Median [IQR] (range)	Statistical analysis (overall p value)
Neonates	2 [1.5–5] (1–5)	4 [2–8] (2–14)	2 [1–4] (0.6–7)	2 [0.9–4] (0.6–7)	0.241
Infants	3	6 [3–22] (3–41)	14 [5–30] (1–60)	10 [5–16] (0.6–16)	0.546
Children	20 [14–40] (9–50)	23 [10–30] (2–55)	18 [8–22] (1–60)	14 [6–20] (2–77)	0.041
Adolescents	35	32 [21–35] (21–35)	16 [7–18] (7–18)	8 [8–11] (8–11)	0.042
Mixed age	15 [7–27] (7–27)	13 [11–24] (5–24)	12 [5–16] (3–24)	10 [5–17] (0.6–50)	0.284
Total	8 [3–22] (1–50)	14 [6–25] (2–55)	12 [5–21] (0.6–60)	10 [5–18] (0.6–77)	0.213