Table 2. Meta-analysis for associations between KIAA0319 polymorphisms and DD.
| KIAA0319 markers | No.* | Study population | MAF in controls# | Sample sizecases/controls (families) | OR (95% CI) | P value | Heterogeneity |
Model for meta-analysis | Egger’s test |
||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Q statistic (P value) | I2 (%) | z | P value | ||||||||
| rs4504469 | 8 | Total | 0.13~0.43 | 2439/2443 and 347 | 1.04 (0.85–1.27) | 0.706 | 32.375 (<0.001) | 82.27 | Random | 1.034 | 0.301 |
| 4 | European | 0.40~0.43 | 1827/1786 | 0.90 (0.83–0.99) | 0.028 | 5.427 (0.143) | 45.11 | Fix | −1.552 | 0.121 | |
| 2 | Asian | 0.13, 0.26 | 612/657 | 1.56 (1.28–1.90) | <0.001 | 0.210 (0.647) | 0.00 | Fix | – | – | |
| 2 | North American | – | 347 | 1.03 (0.71–1.48) | 0.889 | 2.535 (0.111) | 60.55 | Fix | – | – | |
| rs761100 | 5 | Total | 0.39~0.46 | 1827/1786 and 156 | 0.95 (0.75–1.21) | 0.689 | 20.002 (<0.001) | 83.28 | Random | −0.472 | 0.637 |
| 4 | European | 0.39~0.46 | 1827/1786 | 0.99 (0.75–1.31) | 0.951 | 18.207 (<0.001) | 87.18 | Random | 0.089 | 0.929 | |
| 1 | North American | – | 156 | 0.78 (0.55–1.10) | 0.155 | – | – | – | – | – | |
| rs6935076 | 4 | Total | 0.35, 0.36 | 1308/1423 and 347 | 1.01 (0.75–1.37) | 0.930 | 13.957 (0.003) | 83.65 | Random | −0.794 | 0.427 |
| 2 | European | 0.35, 0.36 | 1308/1423 | 1.17 (0.83–1.63) | 0.371 | 6.273 (0.012) | 84.06 | Random | – | – | |
| 2 | North American | – | 347 | 0.85 (0.49–1.45) | 0.540 | 5.135 (0.023) | 80.53 | Random | – | – | |
| rs3212236 | 8 | Total | 0.17~0.35 | 2037/2042 and 752 | 0.94 (0.85–1.04) | 0.233 | 7.812 (0.349) | 17.94 | Fix | −0.433 | 0.665 |
| 5 | European | 0.17~0.19 | 1827/1786 and 304 | 0.95 (0.84–1.06) | 0.327 | 3.675 (0.452) | 15.81 | Fix | −1.324 | 0.185 | |
| 1 | Asian | 0.35 | 210/256 | 0.75 (0.55–1.01) | 0.056 | – | – | – | – | – | |
| 2 | North American | – | 448 | 1.14 (0.85–1.53) | 0.375 | 0.150 (0.698) | 0.00 | Fix | – | – | |
| rs9461045 | 7 | Total | 0.18~0.42 | 2361/2718 and 156 | 0.93 (0.84–1.02) | 0.114 | 4.727 (0.579) | 0.00 | Fix | −0.094 | 0.925 |
| 4 | European | 0.18~0.19 | 1749/2061 | 0.98 (0.87–1.10) | 0.678 | 1.841 (0.606) | 0.00 | Fix | 0.368 | 0.713 | |
| 2 | Asian | 0.39, 0.42 | 612/657 | 0.82 (0.68–0.98) | 0.026 | 0.154 (0.695) | 0.00 | Fix | – | – | |
| 1 | North American | – | 156 | 0.94 (0.64–1.39) | 0.770 | – | – | – | – | – | |
| rs2143340 | 5 | Total | 0.15~0.16 | 1827/1786 and 156 | 1.03 (0.91–1.16) | 0.653 | 3.898 (0.420) | 0.01 | Fix | 0.489 | 0.625 |
| 4 | European | 0.15~0.16 | 1827/1786 | 1.01 (0.89–1.14) | 0.903 | 2.243 (0.523) | 0.00 | Fix | −0.479 | 0.632 | |
| 1 | North American | – | 156 | 1.41 (0.86–2.31) | 0.175 | – | – | – | – | – | |
*The number of studies.
#The range of minor allele frequency (MAF) in the control group of the included studies.