Table 2. Discriminative performance of collagen remodeling biomarkers for detecting metastatic colorectal cancer (stage IV) versus non-metastatic (stage I–III).

Biomarker	Cut-off value (ng/mL)	Sensitivity	Specificity	AUROC (95% CI)	p-value
C1M	30.7	77.8	67.9	0.74 (0.62–0.87)	<0.0001
C3M	11.9	85.7	65.5	0.78 (0.66–0.89)	<0.0001
C4M	52.3	96.4	43.0	0.74 (0.61–0.87)	<0.0001
Pro-C3	10.4	88.9	66.1	0.79 (0.65–0.91)	<0.0001