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. 2016 Jul 28;6:30769. doi: 10.1038/srep30769

Figure 3. Juvenile FMR-KO rats have hyper-excitable visual responses.

Figure 3

(a) Representative dEEG (L4) response to 100 ms light flash of a wild-type animal. (b) Representative response of FMR-KO rat. (c) Population mean (P19–24) time-spectrogram of fold-increase over baseline (1 s pre-stimulus) for L4 dEEG for wild-type (above) and FMR-KO (below). All juvenile analysis from Exp2. Time axis is aligned to onset of visual stimulus. Visual responses are divided into primary (0–250 ms) and secondary (300–1200 ms) responses. (d) Population mean of spectral fold-increase over baseline for primary (top) and secondary (bottom) L4 dEEG. Spectral bins with significant difference (p < 0.05) between wild-type and FMR-KO are shown by black dots. (e) Population mean multi-unit peri-stimulus time histogram of fold increase over baseline in firing rates for superficial (L2–4, top) and deep (L5–6, bottom) neurons. (f) Visual response characteristics of single-units. Firing rate change measured by absolute firing-rate (top) during primary response (left) and secondary response (right), and by fold-increase over baseline (2 s pre-stimulus; bottom) for the same periods. Regular spiking (RS; excitatory) and fast-spiking (FS; inhibitory) neurons are graphed separately. ***p < 0.001, *p < 0.05 by t-test.