Figure 2. Intraperitoneal Glucose Tolerance Test (ipGTT) in control mice raised in normal litters (NL, n = 18) or postnatally overfed mice raised in small litters (SL, n = 19) which, at 6 months of age, were assigned to be fed either ad libitum (AL) or with 20% calorie restriction (CR) for 1 month, until they attained 7 months of age (4 groups were constituted: NLAL (n = 9), NLCR (n = 9), SLAL (n = 10) and SLCR (n = 9)).

Evolution blood glucose (A,C) and area under the curve of blood glucose (B,D) after glucose (2 g/kg) administration at 6 months of age before CR (A,B), and after 4 weeks of CR (C,D) *significantly different from NL/NLAL, p < 0.05. ^†significantly different from SLAL, p < 0.001.