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. 2016 Jul 28;6:30817. doi: 10.1038/srep30817

Figure 4. Cardiovascular function assessed by echocardiography in anesthetized mice.

Figure 4

Control mice were raised in normal litters (NL, n = 30) and postnatally overfed mice raised in small litters (SL, n = 39) and, at 6 months of age, when mice were assigned to be fed either ad libitum (AL) or with 20% calorie restriction (CR) for 1 month, until they attained 7 months of age (4 groups were constituted: NLAL (n = 20), NLCR (n = 10), SLAL (n = 19) and SLCR (n = 20)). (A) Evolution of left ventricular ejection fraction (LVEF, in %). (B) Left ventricular internal diameters (LVID) in diastole and in systole at 6 months. (C,D) Changes in left ventricular internal diameters in diastole (C) and systole (D) between 6 and 7 months. *significantly different from NLAL, p < 0.05. †significantly different from SLAL, p < 0.05. ‡significantly different from NLCR, p < 0.05.