Table 3. Echocardiographic measurements in mice at 6 and 7 months old.
| n | 6 months old (before CR) | 7 months old (after CR) | ||||||
|---|---|---|---|---|---|---|---|---|
| NLAL | NLCR | SLAL | SLCR | NLAL | NLCR | SLAL | SLCR | |
| 20 | 10 | 19 | 21 | 20 | 10 | 19 | 21 | |
| HR, bpm | 438 ± 52 | 363 ± 36* | 409 ± 39 | 423 ± 52 | 449 ± 49 | 375 ± 15* | 459 ± 40† | 413 ± 58* |
| LVEF, % | 57 ± 6 | 58 ± 3 | 50 ± 6ǂ | 52 ± 4ǂ | 59 ± 4 | 60 ± 4 | 49 ± 5ǂ | 60 ± 6*† |
| LVEDD, mm | 4.22 ± 0.26 | 3.95 ± 0.14 | 4.45 ± 0.18ǂ | 4.48 ± 0.26ǂ | 4.22 ± 0.26 | 4.06 ± 0.09 | 4.53 ± 0.1ǂ | 4.17 ± 0.31*† |
| LVMN, mg/g | 3.15 ± 0.81 | 3.71 ± 0.35 | 3.63 ± 0.51 | 3.96 ± 0.56ǂ | 3.81 ± 0.54† | 3.68 ± 0.35 | 3.69 ± 0.55 | 4.12 ± 0.9 |
| E/A ratio | 1.36 ± 0.21 | 1.56 ± 0.22 | 1.58 ± 0.24 | 1.76 ± 1.26 | 1.34 ± 0.12 | 1.49 ± 0.16 | 1.50 ± 0.50 | 1.73 ± 0.48 |
| E/E' | 39 ± 5 | 40 ± 9 | 39 ± 10 | 37 ± 9 | 41 ± 8 | 44 ± 11 | 43 ± 11 | 47 ± 8 |
| Tei index | 0.63 ± 0.13 | 0.70 ± 0.11 | 0.64 ± 0.10 | 0.75 ± 0.18 | 0.76 ± 0.08 | 0.75 ± 0.15 | 0.71 ± 0.10 | 0.71 ± 0.10 |
Data are means ± standard deviation. Bpm indicates beats per minute; HR: heart rate; LVEF: left ventricular ejection fraction; LVEDD: left ventricular end-diastolic diameter; LVMN: left ventricular mass normalized to body weight; n: number of mice.
*p < 0.05 significant difference in comparison with corresponding AL group.
†p < 0.05 significant difference in comparison with the same group at 6 months old.
ǂp < 0.05 significant difference in comparison with NLAL group at the same age.